ArticleMolecular plant pathology2016
Identification and characterization of parasitism genes from the pinewood nematode Bursaphelenchus xylophilus reveals a multilayered detoxification strategy.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 109 citations in OpenAlex.
- From Sequential Gland Replacement to Recurrent Gland Coordination: A Comparative Framework for Subventral and Dorsal Oesophageal Gland Effectors Across Plant-Parasitic Nematode Lifestyles.Plants (Basel, Switzerland) · 2026Review
- A neprilysin effector from the pinewood nematode Bursaphelenchus xylophilus targets pine caffeic acid O-methyltransferase and inhibits lignin biosynthesis.Pest management science · 2026Article
- The stage-specific regulation and role of root-knot nematode SWEET genes.PLoS pathogens · 2026Article
- Cloning and functional analysis of glutathione S-transferase geneFrontiers in plant science · 2026Article
- Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.Biomolecules · 2025Review
- Mycobiome of Pinus pinaster trees naturally infected by the pinewood nematode Bursaphelenchus xylophilus.Scientific reports · 2025Article
- Diet-regulated transcriptional plasticity of plant parasites in plant-mutualist environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Plant Diseases and Sustainable Agriculture.Plants (Basel, Switzerland) · 2025Article
- Exploring the infection strategy ofFrontiers in plant science · 2025Article
- Detection Methods for Pine Wilt Disease: A Comprehensive Review.Plants (Basel, Switzerland) · 2024Review
- TheInternational journal of molecular sciences · 2024Article
- Pine wilt disease: what do we know from proteomics?BMC plant biology · 2024Review
- Functional Characterization of ShK Domain-Containing Protein in the Plant-Parasitic NematodePlants (Basel, Switzerland) · 2024Article
- Effect of Associated Bacteria GD1 on the Low-Temperature Adaptability ofMicroorganisms · 2023Article
- Comparative effects of twoFrontiers in microbiology · 2023Article
- Molecular Defense Response of Pine Trees (Cells · 2022Review
- Roles of Species-Specific Legumains in Pathogenicity of the Pinewood NematodeInternational journal of molecular sciences · 2022Article
- AInternational journal of molecular sciences · 2022Article
- MicroRNA-mediated post-transcriptional regulation of Pinus pinaster response and resistance to pinewood nematode.Scientific reports · 2022Article
- The key molecular pattern BxCDP1 ofFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The migratory endoparasitic nematode Bursaphelenchus xylophilus, which is the causal agent of pine wilt disease, has phytophagous and mycetophagous phases during its life cycle. This highly unusual feature distinguishes it from other plant-parasitic nematodes and requires profound changes in biology between modes. During the phytophagous stage, the nematode migrates within pine trees, feeding on the contents of parenchymal cells. Like other plant pathogens, B. xylophilus secretes effectors from pharyngeal gland cells into the host during infection. We provide the first description of changes in the morphology of these gland cells between juvenile and adult life stages. Using a comparative transcriptomics approach and an effector identification pipeline, we identify numerous novel parasitism genes which may be important for the mediation of interactions of B. xylophilus with its host. In-depth characterization of all parasitism genes using in situ hybridization reveals two major categories of detoxification proteins, those specifically expressed in either the pharyngeal gland cells or the digestive system. These data suggest that B. xylophilus incorporates effectors in a multilayer detoxification strategy in order to protect itself from host defence responses during phytophagy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.