Observational studyWorld journal of urology2016
Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma.
Observational study in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Epidemiology of Primary Urethral Cancer: Insights from Four European Countries with a Focus on Poland.Cancers · 2026Article
- Robot-assisted laparoscopic management of primary urethra clear cell adenocarcinoma in females: a case report and literature review.Frontiers in surgery · 2026Article
- A Systematic Review of the Clinical Features, Management, and Outcomes in Urethral Squamous Cell Carcinoma.Cureus · 2025Review
- Locally advanced primary urethral carcinoma in an HIV-positive female patient: report of a case successfully managed with definitive concurrent chemoradiotherapy at a referral cancer center in Abidjan.Urology case reports · 2025Article
- Primary signet ring cell carcinoma of the female urethra: A case report.World journal of clinical cases · 2025Article
- Primary urethral cancer: Treatment patterns, responses and survival in localized, advanced and metastatic patients.BJUI compass · 2025Article
- Effect of chemotherapy on cancer specific mortality in female locally advanced urethral cancer.World journal of urology · 2025Article
- Primary large cell neuroendocrine carcinoma of the urethra: a case report.Frontiers in urology · 2025Article
- Disitamab Vedotin plus anti-PD-1 antibody show good efficacy in refractory primary urethral cancer with low HER2 expression: a case report.Frontiers in immunology · 2023Article
- A brief review on the diagnostic and therapeutic principles of primary urethral cancer.Asian journal of urology · 2022Review
- Chemotherapy combined with immunotherapy in primary female urethral squamous cell carcinoma: a case report.The Journal of international medical research · 2022Article
- Regional lymph node dissection on men with primary urethral carcinoma.World journal of urology · 2022Article
- Penile sarcomatoid urothelial carcinoma: A case report.Urology case reports · 2021Article
- Primary tumor surgery improves survival in non-metastatic primary urethral carcinoma patients: a large population-based investigation.BMC cancer · 2021Article
- Diagnostic and Therapeutic Challenges of Rare Urogenital Cancers: Urothelial Carcinoma of the Renal Pelvis, Ureters and Urethra.World journal of oncology · 2021Review
- Transperineal-incision urethrectomy combined with laparoscopic prostatectomy for a male patient with squamous cell carcinoma involving distal plus proximal urethra and untypical symptoms-a case report.Translational andrology and urology · 2021Article
- Primary urethral cancer: treatment patterns and associated outcomes.BJU international · 2020Article
- Nomograms for predicting long-term overall survival and cancer-specific survival in patients with primary urethral carcinoma: a population-based study.International urology and nephrology · 2020Article
- Advanced primary urethral cancer: a case report.Journal of medical case reports · 2019Article
- Primary male urethral squamous cell carcinoma presenting with a genital abscess.IJU case reports · 2019Article
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Authors and funding
21 authors.
Funding
Abstract
purposeTo evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC).
methodsA series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death.
resultsMedian age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026).
conclusionsThese data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
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