ArticleCell reports2015
Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Propranolol Reduces Parkinson's Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial.Annals of neurology · 2025Trial
- Somatosensory input drives membrane potential dynamics in motor cortex during voluntary limb movement.PLoS biology · 2026Article
- The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input.PLoS biology · 2025Article
- Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson's disease.Acta pharmacologica Sinica · 2025Review
- Dynamic lateralization in contralateral-projecting corticospinal neurons during motor learning.iScience · 2024Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Areal specializations in the morpho-electric and transcriptomic properties of primate layer 5 extratelencephalic projection neurons.Cell reports · 2024Article
- Astrocyte chloride, excitatory-inhibitory balance and epilepsy.Neural regeneration research · 2024Article
- Frequency Specific Optogenetic Stimulation of the Locus Coeruleus Induces Task-Relevant Plasticity in the Motor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- A cranial implant for stabilizing whole-cell patch-clamp recordings in behaving rodents.Journal of neuroscience methods · 2023Article
- Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice.Nature communications · 2023Article
- Depolarization and Hyperexcitability of Cortical Motor Neurons after Spinal Cord Injury Associates with Reduced HCN Channel Activity.International journal of molecular sciences · 2023Article
- In vivo tractography of human locus coeruleus-relation to 7T resting state fMRI, psychological measures and single subject validity.Molecular psychiatry · 2022Article
- Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types.Science (New York, N.Y.) · 2022Article
- MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning.Molecular brain · 2022Article
- Movement-specific signaling is differentially distributed across motor cortex layer 5 projection neuron classes.Cell reports · 2022Article
- Article
- Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex.Cell reports · 2021Article
- Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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7 authors.
Funding
Abstract
Neuronal activity in primary motor cortex (M1) correlates with behavioral state, but the cellular mechanisms underpinning behavioral state-dependent modulation of M1 output remain largely unresolved. Here, we performed in vivo patch-clamp recordings from layer 5B (L5B) pyramidal neurons in awake mice during quiet wakefulness and self-paced, voluntary movement. We show that L5B output neurons display bidirectional (i.e., enhanced or suppressed) firing rate changes during movement, mediated via two opposing subthreshold mechanisms: (1) a global decrease in membrane potential variability that reduced L5B firing rates (L5Bsuppressed neurons), and (2) a coincident noradrenaline-mediated increase in excitatory drive to a subpopulation of L5B neurons (L5Benhanced neurons) that elevated firing rates. Blocking noradrenergic receptors in forelimb M1 abolished the bidirectional modulation of M1 output during movement and selectively impaired contralateral forelimb motor coordination. Together, our results provide a mechanism for how noradrenergic neuromodulation and network-driven input changes bidirectionally modulate M1 output during motor behavior.
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