Evidence map›Paper›PMID 25980937›Full record

ReviewAdvanced drug delivery reviews2015

MicroRNAs in vascular tissue engineering and post-ischemic neovascularization.

Massimo Caputo, Jaimy Saif, Cha Rajakaruna, Marcus Brooks, Gianni D Angelini, Costanza Emanueli

Open access · hybridAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. MicroRNA-135a-3p regulates angiogenesis and tissue repair by targeting p38 signaling in endothelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. MicroRNAs, signaling pathways and diseases.Annals of translational medicine · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Massimo CaputoBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK; RUSH University Medical Center, Chicago, IL, USA.
Jaimy SaifBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK.
Cha RajakarunaBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK.
Marcus BrooksUniversity Hospital Bristol NHS Trust-Vascular Surgery Unit, Bristol, UK.
Gianni D AngeliniBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK; National Heart and Lung Institute, Imperial College London, London, England, UK.
Costanza EmanueliBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, UK; National Heart and Lung Institute, Imperial College London, London, England, UK. Electronic address: Costanza.Emanueli@bristol.ac.uk.
NIHR Bristol Cardiovascular Biomedical Research Unit · GBUniversity of Bristol · GB

Funding

British Heart Foundation FS/10/001/27959
6 · The paper itself

Abstract

Increasing numbers of paediatric patients with congenital heart defects are surviving to adulthood, albeit with continuing clinical needs. Hence, there is still scope for revolutionary new strategies to correct vascular anatomical defects. Adult patients are also surviving longer with the adverse consequences of ischemic vascular disease, especially after acute coronary syndromes brought on by plaque erosion and rupture. Vascular tissue engineering and therapeutic angiogenesis provide new hope for these patients. Both approaches have shown promise in laboratory studies, but have not yet been able to deliver clear evidence of clinical success. More research into biomaterials, molecular medicine and cell and molecular therapies is necessary. This review article focuses on the new opportunities offered by targeting microRNAs for the improved production and greater empowerment of vascular cells for use in vascular tissue engineering or for increasing blood perfusion of ischemic tissues by amplifying the resident microvascular network.

Indexed as

AneurysmBlood VesselsEndothelial CellsExtracellular MatrixHeart Defects, CongenitalHumansIschemiaMicroRNAsMuscle, Smooth, VascularNeovascularization, PathologicPericytesStem CellsTissue EngineeringMicroRNAsAneurysmsCongenital/acquired heart diseaseIschemic diseaseMicroRNAsTherapeutic angiogenesisVascular tissue engineering

Identifiers

PMID25980937
PMCPMC4728183
OpenAlexW336170717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.