Evidence map›Paper›PMID 25980779›Full record

ReviewSurvey of ophthalmology

Angiogenesis in glaucoma filtration surgery and neovascular glaucoma: A review.

Megan Kim, Chelsea Lee, Rachael Payne, Beatrice Y J T Yue, Jin-Hong Chang, Hongyu Ying

Abstract readReview
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Ultrastructural analysis of explanted CyPass microstents and correlation with clinical findings.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Ahmed glaucoma valve implantation versus suprachoroidal silicone tube implantation following the injection of bevacizumab into the anterior chamber in patients with neovascular glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Megan KimDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.
Chelsea LeeDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.
Rachael PayneDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.
Beatrice Y J T YueDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.
Jin-Hong ChangDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA.
Hongyu YingDepartment of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: hying@uic.edu.
University of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 1985 to 2025
$14.8M
Center for Clinical and Translational ScienceUL1TR000050 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AZAR, DIMITRI T, MERMELSTEIN, ROBIN J. · 2012 to 2014
$9.8M
Inhibition of VEGF receptor dimerization and signaling in corneal lymphangiogenesR21EY021886 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHANG, JIN-HONG · 2011 to 2012
$438k
VEGFR2 Modulates Corneal Angiogenesis and LymphangiogenesisR21EY023691 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CHANG, JIN-HONG · 2013 to 2014
$435k
Endostatin-derived Short Peptides in Corneal TransplantationI01BX002386 · VA · JESSE BROWN VA MEDICAL CENTER · PI CHANG, JIN-HONG · 2014 to 2017
–
BLRD VA I01 BX002386NCATS NIH HHS UL1TR000050NEI NIH HHS EY01792NEI NIH HHS EY021886NEI NIH HHS EY023691NEI NIH HHS P30 EY001792NEI NIH HHS R21 EY021886NEI NIH HHS R21 EY023691
6 · The paper itself

Abstract

Angiogenesis may pose a clinical challenge in glaucoma, for example, during the wound healing phase after glaucoma filtration surgery and in the severe secondary glaucoma called neovascular glaucoma (NVG). Upregulation of vascular endothelial growth factor (VEGF), a key mediator of angiogenesis, occurs in eyes that have undergone glaucoma filtration surgery, as well as those with NVG. This has led investigation of the ability of anti-vascular endothelial growth factor therapy to improve outcomes, and we examine the findings with respect to the safety and efficacy of anti-vascular endothelial growth factor agents, mainly bevacizumab and ranibizumab, in eyes that have undergone glaucoma filtration surgery or have NVG. Combining conventional therapies-such as antimetabolites after filtration surgery and panretinal photocoagulation in NVG-and anti-vascular endothelial growth factor drugs may produce a synergetic effect, although further studies are required to evaluate the long-term efficacy of combination treatments.

Indexed as

Angiogenesis InhibitorsAntimetabolitesBevacizumabCombined Modality TherapyFiltering SurgeryGlaucoma, NeovascularHumansIrisLaser CoagulationNeovascularization, PathologicRanibizumabVascular Endothelial Growth Factor AAngiogenesis InhibitorsAntimetabolitesBevacizumabRanibizumabVascular Endothelial Growth Factor AVEGFA protein, humanangiogenesisanti-metabolitesanti-VEGF therapybevacizumabglaucomaglaucoma filtration surgeryneovascular glaucomaranibizumab

Identifiers

PMID25980779
PMCPMC4615284
OpenAlexW2157501021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.