Muddying the water in brain edema?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

1. Intrathecal drug delivery in the era of nanomedicine.Advanced drug delivery reviews · 2020
   Pooled it
2. New Strategies for the Prevention and Therapy of Alzheimer's Disease Based on Stimulation of Brain Drainage and Lymphatic Clearance.International journal of molecular sciences · 2026
   Review
3. Orchestrating brain fluid dynamics: circadian regulation of CSF, glymphatic exchange, and waste clearance.Frontiers in cell and developmental biology · 2026
   Review
4. Neuro-lymphaphotonics opens new horizons of the future technologies for the therapy of brain diseases.Theranostics · 2026
   Review
5. Sleep is a therapeutic window for photostimulation of drainage of aging brain.Frontiers of optoelectronics · 2025
   Article
6. Brain fluid physiology in ischaemic stroke; more than just oedema.Fluids and barriers of the CNS · 2025
   Review
7. Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient.The Journal of membrane biology · 2025
   Article
8. A Futile Cycle?: Tissue Homeostatic Trans-Membrane Water Co-Transport: Kinetics, Thermodynamics, Metabolic Consequences.bioRxiv : the preprint server for biology · 2024
   Article
9. Mechanisms of Activation of Brain's Drainage during Sleep: The Nightlife of Astrocytes.Cells · 2023
   Review
10. Machine Learning Technology for EEG-Forecast of the Blood-Brain Barrier Leakage and the Activation of the Brain's Drainage System during Isoflurane Anesthesia.Biomolecules · 2023
    Article
11. Aquaporins in Nervous System.Advances in experimental medicine and biology · 2023
    Article
12. Perivascular spaces and their role in neuroinflammation.Neuron · 2022
    Review
13. The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Review
14. The glymphatic hypothesis: the theory and the evidence.Fluids and barriers of the CNS · 2022
    Review
15. Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology.Neuroradiology · 2021
    Review
16. Waste Clearance in the Brain.Frontiers in neuroanatomy · 2021
    Review
17. Magnetic Resonance Imaging and Modeling of the Glymphatic System.Diagnostics (Basel, Switzerland) · 2020
    Review
18. Rebuttal from Alex J. Smith and Alan S. Verkman.The Journal of physiology · 2019
    Article
19. Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases.Fluids and barriers of the CNS · 2019
    Review
20. A transcriptome-based assessment of the astrocytic dystrophin-associated complex in the developing human brain.Journal of neuroscience research · 2018
    Article

Corrections and comments

• Comment on
  Drowning stars: reassessing the role of astrocytes in brain edema.2014

Authors and funding

3 authors at 1 institution in 1 country.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as