Evidence map›Paper›PMID 25980576›Full record

ArticleHeart rhythm2015

2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope.

Robert S Sheldon, Blair P Grubb, Brian Olshansky, Win-Kuang Shen, Hugh Calkins, Michele Brignole, Satish R Raj, Andrew D Krahn, Carlos A Morillo, Julian M Stewart and 10 more

9 registry-linked trialsAbstract readConsensus Statement
In one paragraph

Article in Heart rhythm, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 478 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
478citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03903744 nacompletednot on this mapstarted 2018, after this paper: background citation

CardioneuROablation for Reflex Syncope: Effects on autonoMic cArdiac Regulation and Efficacy Assessment - the Roman Syncope Study.

TypeinterventionalSponsorCentre of Postgraduate Medical EducationRan2018 to 2022Enrolled48ConditionsSyncope, VasovagalArmsCardioneuroablation
NCT04170725 nacompletednot on this mapstarted 2020, after this paper: background citation

Muscular and Cutaneous Dysfunction in Postural Tachycardia Syndrome

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2020 to 2025Enrolled15ConditionsPostural Tachycardia SyndromeArmsPatient and Healthy Volunteers training protocol
NCT04575376 unknown statusnot on this mapstarted 2021, after this paper: background citation

Clinical Audit on Evaluation of Patient With Syncope at Asssiut University Children Hospital

TypeobservationalSponsorAssiut UniversityRan2021 to 2023Enrolled30ConditionsSyncope
NCT04702217 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Physical Activity as a Complementary Treatment in Postural Orthostatic Tachycardia Syndrome - Evaluation of a Structured Physical Activity Program in Clinical Practice

TypeinterventionalSponsorLund UniversityRan2021 to 2022Enrolled0ConditionsPOTSArmsTraining program
NCT04991220 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Evaluation of the Changes of Pleth Variability Index During Preoxygenation for Predicting Hypotension During Induction of Anesthesia in Surgical Patients; Prospective Observational Study

TypeinterventionalSponsorSeoul National University HospitalRan2021 to 2022Enrolled96ConditionsHypotension on InductionArmsPreoxygenation
NCT05280093 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Hybrid Epicardial and Endocardial Sinus Node Sparing Ablation Therapy for Inappropriate Sinus Tachycardia

TypeinterventionalSponsorAtriCure, Inc.Ran2022 to 2028Enrolled142ConditionsInappropriate Sinus TachycardiaArmsAtriCure ISOLATOR Synergy Surgical Ablation System
NCT05907018 completednot on this mapstarted 2023, after this paper: background citation

Comparing Phenotypic and Autonomic Physiologic Determinants of Neurocardiogenic Syncope

TypeobservationalSponsorChildren's Hospital Medical Center, CincinnatiRan2023 to 2024Enrolled40ConditionsSyncope, Chest Pain, Dyspnea
NCT06672861 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ) in Patients With Postural Orthostatic Tachycardia Syndrome, Inappropriate Sinus Tachycardia, and Other Disorders of Cardiac Dysautonomia

TypeinterventionalSponsorKansas City Heart Rhythm Research FoundationRan2026 to 2026Enrolled100ConditionsCardiac DysautonomiaArmsKansas City Cardiac Dysautonomia Questionnaire (KCDysQ)
NCT07019519 narecruitingnot on this mapstarted 2025, after this paper: background citation

Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS

TypeinterventionalSponsorUniversity of CopenhagenRan2025 to 2026Enrolled30ConditionsPostural Orthostatic Tachycardia Syndrome (POTS), HealthyArmsSaline/Placebo, GIPR antagonist, GLP-1R antagonist, CCK agonist
3 · Its place in the literature

Who cites it

478 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Guideline
  5. Pooled it
  6. Trial
  7. Trial
  8. Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Trial
  9. Article
  10. Are we treating the wrong POTS in RECOVER-AUTONOMIC? A call for phenotype subtyping.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  11. Article
  12. Observational
  13. Review
  14. The hidden burden: connective tissue, mast cell, and autoimmune comorbidities cluster in POTS with endometriosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  15. Beta-Blockers for the Treatment of Arrhythmias: Which Drug for Which Arrhythmia? A State-of-the-Art Narrative Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026
    Review
  16. Review
  17. Hyperadrenergic and neuropathic features based on clinical autonomic testing in individuals with POTS: an observational cross-sectional study.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  18. Review
  19. Article
  20. Review

418 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Robert S SheldonLibin Cardiovascular Institute of Alberta, Alberta, Canada. Electronic address: sheldon@ucalgary.ca.
Blair P GrubbUniversity of Toledo, Toledo, Ohio.
Brian OlshanskyThe University of Iowa Hospitals, Iowa City, Iowa.
Win-Kuang ShenMayo Clinic, Phoenix, Arizona.
Hugh CalkinsJohns Hopkins University, Baltimore, Maryland.
Michele BrignoleOspedali del Tigullio, Lavagna, Italy.
Satish R RajLibin Cardiovascular Institute of Alberta, Alberta, Canada; Vanderbilt University School of Medicine, Nashville, Tennessee.
Andrew D KrahnDivision of Cardiology, University of British Columbia, Vancouver, Canada.
Carlos A MorilloDepartment of Medicine, Cardiology Division, McMaster University Population Health Research Institute, Hamilton, Canada.
Julian M StewartNew York Medical College, Valhalla, New York.
Richard SuttonNational Heart and Lung Institute, Imperial College, London, United Kingdom.
Paola SandroniMayo Clinic, Rochester, Minnesota.
Karen J Friday(13)Stanford University School of Medicine, Stanford, California.
Denise Tessariol HachulHeart Institute-University of Sao Paulo Medical School, Sao Paulo, Brazil.
Mitchell I CohenPhoenix Children's Hospital, University of Arizona School of Medicine-Phoenix, Arizona Pediatric Cardiology/Mednax, Phoenix, Arizona.
Dennis H LauCentre for Heart Rhythm Disorders, University of Adelaide; Department of Cardiology, Royal Adelaide Hospital; and South Australian Health and Medical Research Institute, Adelaide, Australia.
Kenneth A MayugaCleveland Clinic, Cleveland, Ohio.
Jeffrey P MoakChildren's National Medical Center, Washington, District of Columbia.
Roopinder K SandhuUniversity of Alberta, Department of Medicine, Division of Cardiology, Alberta, Canada.
Khalil KanjwalMichigan Cardiovascular Institute, Central Michigan University, Saginaw, Michigan.

Funding

Local Vasoconstriction in Postural Tachycardia SyndromeR01HL074873 · NHLBI · NEW YORK MEDICAL COLLEGE · PI STEWART, JULIAN M · 2004 to 2013
$3.4M
Mechanisms of Vasovagal SyncopeR01HL112736 · NHLBI · NEW YORK MEDICAL COLLEGE · PI STEWART, JULIAN M · 2013 to 2016
$2.1M
NHLBI NIH HHS R01 HL074873NHLBI NIH HHS R01 HL112736
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Postural Orthostatic Tachycardia SyndromeSyncope, VasovagalTachycardia, SinusChildFemaleHumansMaleMiddle AgedSocieties, Medical

Identifiers

PMID25980576
PMCPMC5267948

What OpenQuestion holds

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Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.