ReviewIntegrative and comparative biology2015
Rapid Effects of Estradiol on Aggression in Birds and Mice: The Fast and the Furious.
Review in Integrative and comparative biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Neural Bases of Collective Social Behavior and Group Interactions across Species.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Androgen receptor deficiency is associated with reduced aromatase expression in the ventromedial hypothalamus of male cichlids.Annals of the New York Academy of Sciences · 2024Article
- Breaking Through the Bottleneck: Krogh's Principle in Behavioral Neuroendocrinology and the Potential of Gene Editing.Integrative and comparative biology · 2023Review
- Dehydroepiandrosterone (DHEA) increases undirected singing behavior and alters dopaminergic regulation of undirected song in non-breeding male European starlings (Frontiers in endocrinology · 2023Article
- Beyond sex and aggression: testosterone rapidly matches behavioural responses to social context and tries to predict the future.Proceedings. Biological sciences · 2022Article
- From Reductionism Toward Integration: Understanding How Social Behavior Emerges From Integrated Circuits.Frontiers in integrative neuroscience · 2022Review
- Nuclear androgen and progestin receptors inversely affect aggression and social dominance in male zebrafish (Danio rerio).Hormones and behavior · 2021Article
- Impact of Estrogens Present in Environment on Health and Welfare of Animals.Animals : an open access journal from MDPI · 2021Review
- Neuroendocrine patterns underlying seasonal song and year-round territoriality in male black redstarts.Frontiers in zoology · 2021Article
- Ecotype differences in aggression, neural activity and behaviorally relevant gene expression in cichlid fish.Genes, brain, and behavior · 2020Article
- Brain transcriptomics of agonistic behaviour in the weakly electric fish Gymnotus omarorum, a wild teleost model of non-breeding aggression.Scientific reports · 2020Article
- Photoperiod modulates the gut microbiome and aggressive behavior in Siberian hamsters.The Journal of experimental biology · 2020Article
- Signatures of sex: Sex differences in gene expression in the vertebrate brain.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters.Hormones and behavior · 2020Article
- A Teleost Fish Model to Understand Hormonal Mechanisms of Non-breeding Territorial Behavior.Frontiers in endocrinology · 2020Review
- New concepts in the study of the sexual differentiation and activation of reproductive behavior, a personal view.Frontiers in neuroendocrinology · 2019Review
- Sex Differences in the Epigenome: A Cause or Consequence of Sexual Differentiation of the Brain?Genes · 2019Review
- Why Do Birds Flock? A Role for Opioids in the Reinforcement of Gregarious Social Interactions.Frontiers in physiology · 2019Review
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- Gene regulatory mechanisms underlying sex differences in brain development and psychiatric disease.Annals of the New York Academy of Sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Across invertebrates and vertebrates, steroids are potent signaling molecules that affect nearly every cell in the organism, including cells of the nervous system. Historically, researchers have focused on the genomic (or "nuclear-initiated") effects of steroids. However, all classes of steroids also have rapid non-genomic (or "membrane-initiated") effects, although there is far less basic knowledge of these non-genomic effects. In particular, steroids synthesized in the brain ("neurosteroids") have genomic and non-genomic effects on behavior. Here, we review evidence that estradiol has rapid effects on aggression, an important social behavior, and on intracellular signaling cascades in relevant regions of the brain. In particular, we focus on studies of song sparrows (Melospiza melodia) and Peromyscus mice, in which estradiol has rapid behavioral effects under short photoperiods only. Furthermore, in captive Peromyscus, estrogenic compounds (THF-diols) in corncob bedding profoundly alter the rapid effects of estradiol. Environmental factors in the laboratory, such as photoperiod, diet, and bedding, are critical variables to consider in experimental design. These studies are consistent with the hypothesis that locally-produced steroids are more likely than systemic steroids to act via non-genomic mechanisms. Furthermore, these studies illustrate the dynamic balance between genomic and non-genomic signaling for estradiol, which is likely to be relevant for other steroids, behaviors, and species.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.