ReviewPediatric nephrology (Berlin, Germany)2016
Haematuria as a risk factor for chronic kidney disease progression in glomerular diseases: A review.
Review in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Chronic kidney disease progression in glomerular diseases: is hematuria a key risk factor?Pediatric nephrology (Berlin, Germany) · 2026Review
- Open-label Randomized Controlled Trial of Controlled-release Formulation Budesonide in Indian Proteinuric IgA Nephropathy Patients.Kidney medicine · 2026Article
- Detection of Alport gene variants in children and young people with persistent haematuria.Pediatric nephrology (Berlin, Germany) · 2025Article
- Pump-Free Microfluidics for Cell Concentration Analysis on Smartphones in Clinical Settings (SmartFlow): Design, Development, and Evaluation.JMIR biomedical engineering · 2024Article
- Noninvasive genetic testing for type IV collagen nephropathy using oral mucosa DNA sampling in children with haematuria.Renal failure · 2024Article
- Association between gingival bleeding and hematuria as biomarkers of periodontitis and renal disease: a review.Odontology · 2024Review
- The Impact of BMI Changes on the Incidence of Glomerular Hematuria in Korean Adults: A Retrospective Study Based on the NHIS-HEALS Cohort.Biomedicines · 2023Article
- Association between microscopic hematuria and albuminuria in patients with chronic kidney disease caused by diabetes and hypertension: the Fukuoka Kidney disease Registry Study.Clinical and experimental nephrology · 2023Article
- Collapsing focal segmental glomerulosclerosis secondary to COVID-19: A systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Article
- An evaluation of the roles of hematuria and uric acid in defining the prognosis of patients with IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2022Review
- Clinical outcomes in pediatric patients with normal renal histopathology.Kidney research and clinical practice · 2022Article
- Clinical Outcomes of Patients With Primary Membranous Nephropathy and Subnephrotic Proteinuria.Frontiers in medicine · 2021Article
- Microhematuria Enhances the Risks of Relapse and Renal Progression in Primary Membranous Nephropathy.Frontiers in medicine · 2021Article
- Microscopic hematuria is a risk factor for end-stage kidney disease in patients with biopsy-proven diabetic nephropathy.BMJ open diabetes research & care · 2020Article
- Acute Kidney Injury due to Anticoagulant-Related Nephropathy : A Suggestion for Therapy.Case reports in nephrology · 2020Article
- Hematuria and Proteinuria in Children.Pediatrics in review · 2018Review
- Persistent Microscopic Hematuria as a Risk Factor for Progression of IgA Nephropathy: New Floodlight on a Nearly Forgotten Biomarker.Journal of the American Society of Nephrology : JASN · 2017Article
- Remission of Hematuria Improves Renal Survival in IgA Nephropathy.Journal of the American Society of Nephrology : JASN · 2017Article
- Comparison of methods of steroid administration combined with tonsillectomy for IgA nephropathy patients.Clinical and experimental nephrology · 2017Article
- Significance of clinical and morphological prognostic risk factors in IgA nephropathy: follow-up study of comparison patient groups with and without renoprotection.BMC nephrology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haematuria has long been considered to be a benign condition associated with glomerular diseases. However, new evidences suggest that haematuria has a pathogenic role in promoting kidney disease progression. An increased risk for end-stage renal disease has been reported in adolescents and young adults with persistent microscopic haematuria. A persistent impairment of renal function has been also reported following macroscopic haematuria-associated acute kidney injury in immunoglobulin A nephropathy. Haematuria-induced renal damage has been related to oxidant, cytotoxic and inflammatory effects induced by haemoglobin or haem released from red blood cells. The pathophysiological origin of haematuria may be due to a more fragile and easily ruptured glomerular filtration barrier, as reported in several glomerular diseases. In this review we describe a number of the key issues associated with the epidemiology and pathogenesis of haematuria-associated diseases, provide an update of recent knowledge on the role of haematuria on renal function outcome and discuss specific therapeutic approaches in this setting. KEY SUMMARY POINTS: 1. Glomerular haematuria is a common observation in a number of renal diseases that may lead to persistent renal injury. 2. Haematuria in children differs from that in adults in specific aspects, particularly in the frequency of glomerular diseases and renal disease outcome. 3. Regular follow-up of renal function in children with isolated microhaematuria may be recommended.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.