ArticleEnvironmental microbiology2016
Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions.
Article in Environmental microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery.Natural product reports · 2026Review
- Drought preceding rain events drives shifts in phytoplankton composition and metabolome in Lake Aydat (France) revealing molecular strategies.FEMS microbiology ecology · 2026Article
- Secondary metabolism ofApplied and environmental microbiology · 2026Review
- Diverse Cyanopeptides follow distinct temporal succession patterns in freshwater harmful algal blooms.The ISME journal · 2026Article
- Unveiling the Diversity of Periphytic Cyanobacteria (Cyanophyceae) from Tropical Mangroves in Penang, Malaysia.Tropical life sciences research · 2023Article
- Cyanotoxins and Other Bioactive Compounds from the Pasteur Cultures of Cyanobacteria (PCC).Toxins · 2023Review
- Metabolomics Applied to Cyanobacterial Toxins and Natural Products.Advances in experimental medicine and biology · 2023Review
- Interspecific Interactions Drive Nonribosomal Peptide Production in Nodularia spumigena.Applied and environmental microbiology · 2022Article
- Role is in the eye of the beholder-the multiple functions of the antibacterial compound tropodithietic acid produced by marine Rhodobacteraceae.FEMS microbiology reviews · 2022Article
- Anabaenopeptins: What We Know So Far.Toxins · 2021Review
- Competitive interactions as a mechanism for chemical diversity maintenance in Nodularia spumigena.Scientific reports · 2021Article
- Current Knowledge on Microviridin from Cyanobacteria.Marine drugs · 2021Review
- Insight into Unprecedented Diversity of Cyanopeptides in Eutrophic Ponds Using an MS/MS Networking Approach.Toxins · 2020Article
- The Effects of Cyanobacterial Bloom Extracts on the Biomass, Chl-a, MC and Other Oligopeptides Contents in a NaturalInternational journal of environmental research and public health · 2020Article
- Investigation of In Vitro Endocrine Activities ofToxins · 2020Article
- Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach.Journal of natural products · 2020Article
- The Composition and Function of Microbiomes WithinFrontiers in microbiology · 2020Article
- Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model.PloS one · 2020Article
- Metabolome Variation between Strains ofToxins · 2019Article
- Physiological and Metabolic Responses of Freshwater and Brackish-Water Strains of Microcystis aeruginosa Acclimated to a Salinity Gradient: Insight into Salt Tolerance.Applied and environmental microbiology · 2019Article
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5 authors at 5 institutions in 2 countries.
Funding
Abstract
The cyanobacteria Microcystis proliferate in freshwater ecosystems and produce bioactive compounds including the harmful toxins microcystins (MC). These secondary metabolites play an important role in shaping community composition through biotic interactions although their role and mode of regulation are poorly understood. As natural cyanobacterial populations include producing and non-producing strains, we tested if the production of a range of peptides by coexisting cells could be regulated through intraspecific interactions. With an innovative co-culturing chamber together with advanced mass spectrometry (MS) techniques, we monitored the growth and compared the metabolic profiles of a MC-producing as well as two non-MC-producing Microcystis strains under mono- and co-culture conditions. In monocultures, these strains grew comparably; however, the non-MC-producing mutant produced higher concentrations of cyanopeptolins, aerucyclamides and aeruginosins than the wild type. Physiological responses to co-culturing were reflected in a quantitative change in the production of the major peptides. Using a MS/MS-based molecular networking approach, we identified new analogues of known classes of peptides as well as new compounds. This work provides new insights into the factors that regulate the production of MC and other secondary metabolites in cyanobacteria, and suggests interchangeable or complementary functions allowing bloom-forming cyanobacteria to efficiently colonize and dominate in fluctuating aquatic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.