ArticleAmerican journal of physiology. Cell physiology2015
Endoplasmic reticulum and oxidant stress mediate nuclear factor-κB activation in the subfornical organ during angiotensin II hypertension.
Article in American journal of physiology. Cell physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Role of Sigma-1 Receptors in the Paraventricular Nucleus and Myocardium during Cirrhotic Cardiomyopathy in Rats.Molecular neurobiology · 2026Article
- Neuro-renin-angiotensin-aldosterone system axis in alzheimer's disease: from molecular dysregulation to therapeutic redirection.Metabolic brain disease · 2026Review
- Sensory Circumventricular Organ Insulin Signaling in Cardiovascular and Metabolic Regulation.Current issues in molecular biology · 2025Review
- Kinin B1R Activation Induces Endoplasmic Reticulum Stress in Primary Hypothalamic Neurons.Frontiers in pharmacology · 2022Article
- Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation.Metabolites · 2021Review
- Interactions of the Brain Renin-Angiotensin-System (RAS) and Inflammation in the Sensitization of Hypertension.Frontiers in neuroscience · 2020Review
- Subfornical organ insulin receptors tonically modulate cardiovascular and metabolic function.Physiological genomics · 2019Article
- Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.Physiological reviews · 2018Review
- Elevated Oxidative Stress and Inflammation in Hypothalamic Paraventricular Nucleus Are Associated With Sympathetic Excitation and Hypertension in Rats Exposed to Chronic Intermittent Hypoxia.Frontiers in physiology · 2018Article
- Endoplasmic Reticulum Stress, a Driver or an Innocent Bystander in Endothelial Dysfunction Associated with Hypertension?Current hypertension reports · 2017Review
- Renin-angiotensin system activation accelerates atherosclerosis in experimental renal failure by promoting endoplasmic reticulum stress-related inflammation.International journal of molecular medicine · 2017Article
- High Salt Intake Augments Excitability of PVN Neurons in Rats: Role of the Endoplasmic Reticulum CaFrontiers in neuroscience · 2017Article
- Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure.American journal of physiology. Heart and circulatory physiology · 2016Article
- A synthetic luciferin improves in vivo bioluminescence imaging of gene expression in cardiovascular brain regions.Physiological genomics · 2016Article
- Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Endoplasmic reticulum stress: a novel mechanism and therapeutic target for cardiovascular diseases.Acta pharmacologica Sinica · 2016Review
- Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure Rats.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Neuroendocrinological and Epigenetic Mechanisms Subserving Autonomic Imbalance and HPA Dysfunction in the Metabolic Syndrome.Frontiers in neuroscience · 2016Review
- Neurohumoral Integration of Cardiovascular Function by the Lamina Terminalis.Current hypertension reports · 2015Review
- Angiotensin-II, the Brain, and Hypertension: An Update.Hypertension (Dallas, Tex. : 1979) · 2015Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) generation in the brain circumventricular subfornical organ (SFO) mediate the central hypertensive actions of Angiotensin II (ANG II). However, the downstream signaling events remain unclear. Here we tested the hypothesis that angiotensin type 1a receptors (AT1aR), ER stress, and ROS induce activation of the transcription factor nuclear factor-κB (NF-κB) during ANG II-dependent hypertension. To spatiotemporally track NF-κB activity in the SFO throughout the development of ANG II-dependent hypertension, we used SFO-targeted adenoviral delivery and longitudinal bioluminescence imaging in mice. During low-dose infusion of ANG II, bioluminescence imaging revealed a prehypertensive surge in NF-κB activity in the SFO at a time point prior to a significant rise in arterial blood pressure. SFO-targeted ablation of AT1aR, inhibition of ER stress, or adenoviral scavenging of ROS in the SFO prevented the ANG II-induced increase in SFO NF-κB. These findings highlight the utility of bioluminescence imaging to longitudinally track transcription factor activation during the development of ANG II-dependent hypertension and reveal an AT1aR-, ER stress-, and ROS-dependent prehypertensive surge in NF-κB activity in the SFO. Furthermore, the increase in NF-κB activity before a rise in arterial blood pressure suggests a causal role for SFO NF-κB in the development of ANG II-dependent hypertension.
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