Observational studyClinical journal of the American Society of Nephrology : CJASN2015
Low Triiodothyronine Syndrome and Long-Term Cardiovascular Outcome in Incident Peritoneal Dialysis Patients.
Observational study in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- The association of the serum free triiodothyronine to free thyroxine ratio with contrast-induced nephropathy and long-term outcomes in elective percutaneous coronary intervention: a retrospective study.BMC cardiovascular disorders · 2026Article
- Lactation duration and lifetime progression to metabolic syndrome in women according to their history of gestational diabetes: a prospective longitudinal community-based cohort study.Journal of translational medicine · 2023Article
- Low Free Triiodothyronine as a More Sensitive Predictor of Survival Than Total Testosterone among Dialysis Men.Nutrients · 2023Article
- Kidney disease and thyroid dysfunction: the chicken or egg problem.Pediatric nephrology (Berlin, Germany) · 2022Review
- Correlation and Prognostic Assessment of Low T3 Syndrome and Norepinephrine Dosage for Patients with Sepsis: A Retrospective Single-Center (Cohort) Study.International journal of general medicine · 2022Article
- Low Free Triiodothyronine Level as a Predictor of Cardiovascular Events and All-Cause Mortality in Patients Undergoing Hemodialysis: The DREAM Cohort.Journal of atherosclerosis and thrombosis · 2021Article
- Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- The Correlation Between Low Serum T3 Levels and All-Cause and Cardiovascular Mortality in Peritoneal Dialysis Patients.Therapeutics and clinical risk management · 2021Article
- Nocturnal haemodialysis is associated with a reduced occurrence of low triiodothyronine serum levels in haemodialysed patients.Clinical kidney journal · 2020Article
- THE ASSOCIATION OF LOW TRIIODOTHYRONINE SYNDROME, PROTEIN-ENERGY WASTING AND CHRONIC INFLAMMATION WITH MORTALITY IN PREVALENT DIALYSIS PATIENTS.Acta clinica Croatica · 2018Article
- Lactation Duration and Long-Term Thyroid Function: A Study among Women with Gestational Diabetes.Nutrients · 2018Article
- Thyroid dysfunction and kidney disease: An update.Reviews in endocrine & metabolic disorders · 2017Review
- Thyroid Functional Disease and Mortality in a National Peritoneal Dialysis Cohort.The Journal of clinical endocrinology and metabolism · 2016Observational
- Low Triiodothyronine Syndrome in Patients With Radiation Enteritis: Risk Factors and Clinical Outcomes an Observational Study.Medicine · 2016Observational
- Low-T3 Syndrome in Peritoneal Dialysis: Metabolic Adaptation, Marker of Illness, or Mortality Mediator?Clinical journal of the American Society of Nephrology : CJASN · 2015Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesA direct association between low triiodothyronine (T3) syndrome and cardiovascular (CV) mortality has been reported in hemodialysis patients. However, the implications of this syndrome in peritoneal dialysis (PD) patients have not been properly investigated. This study examined the association between low T3 syndrome and CV mortality including sudden death in a large cohort of incident PD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This prospective observational study included 447 euthyroid patients who started PD between January 2000 and December 2009. Measurement of thyroid hormones was performed at baseline. All-cause and cause-specific deaths were registered during the median 46 months of follow-up. The survival rate was compared among three groups based on tertile of T3 levels.
resultsIn Kaplan-Meyer analysis, patients with the lowest tertile were significantly associated with higher risk of all-cause and CV mortality including sudden death (P<0.001 for trend). In Cox analyses, T3 level was a significant predictor of all-cause mortality (per 10-unit increase, adjusted hazard ratio [HR], 0.86; 95% confidence interval [95% CI], 0.78 to 0.94; P=0.002), CV death (per 10-unit increase, adjusted HR, 0.84; 95% CI, 0.75 to 0.98; P=0.01), and sudden death (per 10-unit increase, adjusted HR, 0.69; 95% CI, 0.56 to 0.86; P=0.001) after adjusting for well known risk factors including inflammation and malnutrition. The higher T3 level was also independently associated with lower risk for sudden death (per 10-unit increase, adjusted HR, 0.71; 95% CI, 0.56 to 0.90; P=0.01) even when accounting for competing risks of death from other causes.
conclusionsT3 level at the initiation of PD was a strong independent predictor of long-term CV mortality, particularly sudden death, even after adjusting well known risk factors. Low T3 syndrome might represent a factor directly implicated in cardiac complications in PD patients.
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