ArticleApplied and environmental microbiology2015
Destruction of the Capsid and Genome of GII.4 Human Norovirus Occurs during Exposure to Metal Alloys Containing Copper.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Engineering copper and copper-based materials for a post-antibiotic era.Frontiers in bioengineering and biotechnology · 2025Review
- Aerosol Transmission of Norovirus.Viruses · 2024Review
- Efficacy of copper blend coatings in reducing SARS-CoV-2 contamination.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Antimicrobial activity of silver-copper coating against aerosols containing surrogate respiratory viruses and bacteria.PloS one · 2023Article
- Efficacy of an alcohol-based surface disinfectant formulation against human norovirus.Journal of applied microbiology · 2022Article
- Efficacy and Mechanisms of Copper Ion-Catalyzed Inactivation of Human Norovirus.ACS infectious diseases · 2022Article
- Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Review
- Quantitative Evaluation of Nucleic Acid Degradability of Copper Alloy Surfaces and Its Correlation to Antibacterial Activity.Antibiotics (Basel, Switzerland) · 2021Article
- Virus matrix interference on assessment of virucidal activity of high-touch surfaces designed to prevent hospital-acquired infections.Antimicrobial resistance and infection control · 2021Article
- The effect of proteolytic enzymes and pH on GII.4 norovirus, during both interactions and non-interaction with Histo-Blood Group Antigens.Scientific reports · 2020Article
- Article
- Effects of Contamination of Freshwater Habitat With Common Heavy Metals and Anions on the Prevalence of Human Adenoviruses and Enteroviruses.Frontiers in public health · 2020Article
- Cold argon-oxygen plasma species oxidize and disintegrate capsid protein of feline calicivirus.PloS one · 2018Article
- Resistance of Enteric Viruses on Fomites.Intervirology · 2018Review
- Alternative In Vitro Methods for the Determination of Viral Capsid Structural Integrity.Journal of visualized experiments : JoVE · 2017Article
- Efficacy of Neutral Electrolyzed Water for Inactivation of Human Norovirus.Applied and environmental microbiology · 2017Article
- A large outbreak of acute gastroenteritis caused by the human norovirus GII.17 strain at a university in Henan Province, China.Infectious diseases of poverty · 2017Article
- Virucidal Activity of Fogged Chlorine Dioxide- and Hydrogen Peroxide-Based Disinfectants against Human Norovirus and Its Surrogate, Feline Calicivirus, on Hard-to-Reach Surfaces.Frontiers in microbiology · 2017Article
- Human norovirus binding to select bacteria representative of the human gut microbiota.PloS one · 2017Article
- Nanoparticles: Alternatives Against Drug-Resistant Pathogenic Microbes.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human norovirus (HuNoV) represents a significant public health burden worldwide and can be environmentally transmitted. Copper surfaces have been shown to inactivate the cultivable surrogate murine norovirus, but no such data exist for HuNoV. The purpose of this study was to characterize the destruction of GII.4 HuNoV and virus-like particles (VLPs) during exposure to copper alloy surfaces. Fecal suspensions positive for a GII.4 HuNoV outbreak strain or GII.4 VLPs were exposed to copper alloys or stainless steel for 0 to 240 min and recovered by elution. HuNoV genome integrity was assessed by reverse transcription-quantitative PCR (RT-qPCR) (without RNase treatment), and capsid integrity was assessed by RT-qPCR (with RNase treatment), transmission electron microscopy (TEM), SDS-PAGE/Western blot analysis, and a histo-blood group antigen (HBGA) binding assay. Exposure of fecal suspensions to pure copper for 60 min reduced the GII.4 HuNoV RNA copy number by ∼3 log10 units when analyzed by RT-qPCR without RNase treatment and by 4 log10 units when a prior RNase treatment was used. The rate of reduction of the HuNoV RNA copy number was approximately proportional to the percentage of copper in each alloy. Exposure of GII.4 HuNoV VLPs to pure-copper surfaces resulted in noticeable aggregation and destruction within 240 min, an 80% reduction in the VP1 major capsid protein band intensity in 15 min, and a near-complete loss of HBGA receptor binding within 8 min. In all experiments, HuNoV remained stable on stainless steel. These results suggest that copper surfaces destroy HuNoV and may be useful in preventing environmental transmission of the virus in at-risk settings.
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