Evidence map›Paper›PMID 25979893›Full record

ArticleApplied and environmental microbiology2015

Microbiota at Multiple Body Sites during Pregnancy in a Rural Tanzanian Population and Effects of Moringa-Supplemented Probiotic Yogurt.

Jordan E Bisanz, Megan K Enos, George PrayGod, Shannon Seney, Jean M Macklaim, Stephanie Chilton, Dana Willner, Rob Knight, Christoph Fusch, Gerhard Fusch and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Characterizing the supragingival microbiome of healthy pregnant women.Frontiers in cellular and infection microbiology · 2022
    Trial
  6. Nutrients · 2021
    Trial
  7. Trial
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Exploring the Potential ofInternational journal of medical sciences · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Jordan E BisanzDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Megan K EnosDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
George PrayGodNational Institute for Medical Research, Mwanza, Tanzania.
Shannon SeneyCanadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Jean M MacklaimDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Stephanie ChiltonDepartment of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Dana WillnerDepartment of Statistics, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.
Rob KnightHoward Hughes Medical Institute, BioFrontiers Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado, USA.
Christoph FuschDepartment of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
Gerhard FuschDepartment of Paediatrics, McMaster University, Hamilton, Ontario, Canada.
Gregory B GloorDepartment of Biochemistry, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Jeremy P BurtonDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada Department of Surgery, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada.
Gregor ReidDepartment of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada Department of Surgery, The University of Western Ontario, London, Ontario, Canada Canadian Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, Ontario, Canada gregor@uwo.ca.
Western University · CALawson Health Research Institute · CAMcMaster University · CAHoward Hughes Medical Institute · USNational Institute for Medical Research · TZUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nutritional status of pregnant women is vital for healthy outcomes and is a concern for a large proportion of the world's population. The role of the microbiota in pregnancy and nutrition is a promising new area of study with potential health ramifications. In many African countries, maternal and infant death and morbidity are associated with malnutrition. Here, we assess the influence of probiotic yogurt containing Lactobacillus rhamnosus GR-1, supplemented with Moringa plant as a source of micronutrients, on the health and oral, gut, vaginal, and milk microbiotas of 56 pregnant women in Tanzania. In an open-label study design, 26 subjects received yogurt daily, and 30 were untreated during the last two trimesters and for 1 month after birth. Samples were analyzed using 16S rRNA gene sequencing, and dietary recalls were recorded. Women initially categorized as nourished or undernourished consumed similar calories and macronutrients, which may explain why there was no difference in the microbiota at any body site. Consumption of yogurt increased the relative abundance of Bifidobacterium and decreased Enterobacteriaceae in the newborn feces but had no effect on the mother's microbiota at any body site. The microbiota of the oral cavity and GI tract remained stable over pregnancy, but the vaginal microbiota showed a significant increase in diversity leading up to and after birth. In summary, daily micronutrient-supplemented probiotic yogurt provides a safe, affordable food for pregnant women in rural Tanzania, and the resultant improvement in the gut microbial profile of infants is worthy of further study.

Indexed as

MicrobiotaMoringaYogurtBacteriaCluster AnalysisDietDNA, BacterialDNA, RibosomalFemaleGastrointestinal TractHumansInfantInfant, NewbornMilk, HumanMolecular Sequence DataMouth MucosaDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S

Identifiers

PMID25979893
PMCPMC4495201
OpenAlexW1874616036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.