Evidence map›Paper›PMID 25979705›Full record

ArticleBiology open2015

The insulator protein CTCF regulates Drosophila steroidogenesis.

Ujué Fresán, Sergi Cuartero, Michael B O'Connor, M Lluisa Espinàs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ujué FresánInstitute of Molecular Biology of Barcelona, IBMB-CSIC, and Institute for Research in Biomedicine IRB, Barcelona 08028, Spain.
Sergi CuarteroInstitute of Molecular Biology of Barcelona, IBMB-CSIC, and Institute for Research in Biomedicine IRB, Barcelona 08028, Spain.
Michael B O'ConnorDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
M Lluisa EspinàsInstitute of Molecular Biology of Barcelona, IBMB-CSIC, and Institute for Research in Biomedicine IRB, Barcelona 08028, Spain Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA mlebmc@ibmb.csic.es.
Institute for Research in Biomedicine · ESUniversity of Minnesota · US

Funding

Control of developmental timing and body size in DrosophilaR01GM093301 · NIGMS · UNIVERSITY OF MINNESOTA · PI O'CONNOR, MICHAEL BRENDAN · 2010 to 2013
$1.4M
NIGMS NIH HHS R01 GM093301
6 · The paper itself

Abstract

The steroid hormone ecdysone is a central regulator of insect development. In this report we show that CTCF expression in the prothoracic gland is required for full transcriptional activation of the Halloween genes spookier, shadow and noppera-bo, which encode ecdysone biosynthetic enzymes, and for proper timing of ecdysone-responsive gene expression. Loss of CTCF results in delayed and less synchronized larval development that can only be rescued by feeding larvae with both, the steroid hormone 20-hydroxyecdysone and cholesterol. Moreover, CTCF-knockdown in prothoracic gland cells leads to increased lipid accumulation. In conclusion, the insulator protein CTCF is required for Halloween gene expression and cholesterol homeostasis in ecdysone-producing cells controlling steroidogenesis.

Indexed as

CTCFDevelopmental timingEcdysoneHalloween genes

Identifiers

PMID25979705
PMCPMC4571099
OpenAlexW2129866458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.