Evidence map›Paper›PMID 25979674›Full record

ArticleGene2015

The C57BL/6J Niemann-Pick C1 mouse model with decreased gene dosage is susceptible to increased weight gain when fed a high-fat diet: Confirmation of a gene-diet interaction.

David Jelinek, Joseph J Castillo, Randall A Heidenreich, William S Garver

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David JelinekDepartment of Biochemistry and Molecular Biology, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Joseph J CastilloDepartment of Biochemistry and Molecular Biology, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Randall A HeidenreichDepartment of Pediatrics, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
William S GarverDepartment of Biochemistry and Molecular Biology, School of Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address: wgarver@unm.edu.

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Insulin Resistance and ABCA1 Transporter FunctionR21DK071544 · NIDDK · UNIVERSITY OF ARIZONA · PI GARVER, WILLIAM S · 2005 to 2006
$372k
NCATS NIH HHS UL1 TR001449NIDDK NIH HHS DK071544NIDDK NIH HHS R21 DK071544
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsDiet, High-FatDisease Models, AnimalFemaleGene DosageGene-Environment InteractionIntracellular Signaling Peptides and ProteinsMaleMice, Inbred C57BLNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CObesityProteinsWeight GainIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNpc1 protein, mouseProteinsGene-diet interactionImpaired glucose toleranceMouse modelNiemann–Pick C1Weight gain

Identifiers

PMID25979674
PMCPMC4483511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.