Evidence map›Paper›PMID 25979468›Full record

ReviewAdvanced drug delivery reviews2015

An overview of microRNAs.

Scott M Hammond

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 754 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
754citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

754 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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694 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Scott M HammondDepartment of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: hammond@med.unc.edu.

Funding

A Link between RNAi and Fragile X Mental RetardationR01GM070674 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAMMOND, SCOTT M · 2005 to 2009
$1.4M
Micro RNA Regulation of Human Airway Epithelial PhenotypeRC1HL100108 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAMMOND, SCOTT M, HAYES, DAVID N · 2009 to 2010
$1000k
NHLBI NIH HHS RC1 HL100108NHLBI NIH HHS RC1HL100108NIGMS NIH HHS R01 GM070674NIGMS NIH HHS R01GM070674
6 · The paper itself

Abstract

The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome. miRNAs have been linked to many human diseases and are being pursued as clinical diagnostics and as therapeutic targets. This review presents an overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches.

Indexed as

Drug DiscoveryMicroRNAsAnimalsHumansMetabolic DiseasesMolecular Targeted TherapyNeoplasmsOligonucleotides, AntisenseRibonuclease IIIRNA InterferenceMicroRNAsOligonucleotides, AntisenseRibonuclease IIIArgonauteDicerDroshaMicroRNAmiRNARNAi

Identifiers

PMID25979468
PMCPMC4504744

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.