Evidence map›Paper›PMID 25979348›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2015

Self-reported Medication Adherence and Adverse Patient Safety Events in CKD.

Kailin L Hsu, Jeffrey C Fink, Jennifer S Ginsberg, Marni Yoffe, Min Zhan, Wanda Fink, Corinne M Woods, Clarissa J Diamantidis

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Article
  8. Article
  9. [Polypharmacy in acute and chronic kidney diseases].Innere Medizin (Heidelberg, Germany) · 2024
    Review
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  17. Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece.International journal of environmental research and public health · 2020
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kailin L HsuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Jeffrey C FinkDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD; Department of Medicine, Veterans Affairs Maryland Health Care System, Baltimore, MD.
Jennifer S GinsbergDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Marni YoffeDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Min ZhanDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD.
Wanda FinkDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Corinne M WoodsUniversity of Maryland School of Pharmacy, Baltimore, MD.
Clarissa J DiamantidisDepartment of Medicine, Duke University School of Medicine, Durham, NC; Department of Medicine, Durham Veterans Affairs Medical Center, Durham, NC. Electronic address: clarissa.diamantidis@duke.edu.

Funding

Does underrecognition of kidney disease affect patient safety?R01DK084017 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FINK, JEFFREY C · 2010 to 2014
$2.1M
Short-term Training Program on AgingT35AG036679 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI CAREY, GREGORY B · 2010 to 2014
$704k
NIA NIH HHS T35 AG036679NIA NIH HHS T35AG036679NIDDK NIH HHS R01 DK084017NIDDK NIH HHS R01-DK084017
6 · The paper itself

Abstract

backgroundPromoting medication adherence is a recognized challenge for prescribers. In this study, we examine whether lower medication adherence is associated with adverse safety events in individuals with decreased estimated glomerular filtration rates (eGFRs). STUDY

designCross-sectional baseline analysis of prospective cohort. SETTING &

participantsBaseline analysis of the Safe Kidney Care (SKC) Cohort Study, a prospective study of individuals with eGFRs<60 mL/min/1.73 m(2) intended to assess the incidence of disease-specific safety events. Kidney transplant recipients were excluded. PREDICTOR: Self-reported medication adherence based on responses to 3 questions ascertaining degree of medication regimen adherence. OUTCOMES: Adverse safety events were self-reported at baseline (class I events), such as hypoglycemia or fall thought to be related to a medication, or detected incidentally during the baseline visit (class II events), for example, hypotension or hyperkalemia. Potential drug-related problems (DRPs) were determined by analyzing participants' medications with respect to dosing guidelines based on their screening eGFRs at the time of medication reporting. MEASUREMENTS: Relationship between medication adherence and disease-specific patient safety events.

resultsOf 293 SKC participants, 154 (53%) were classified as having lower medication adherence. After multivariable adjustment, lower medication adherence was significantly associated with a class I or II safety event (prevalence ratio [PR], 1.21; 95% CI, 1.04-1.41) and potential DRPs (PR, 1.29; 95% CI, 1.02-1.63). Lower medication adherence was also significantly associated with multiple (≥2) class I events (PR, 1.71; 95% CI, 1.18-2.49), multiple class I or II events (PR, 1.35; 95% CI, 1.04-1.76), and multiple potential DRPs (PR, 2.11; 95% CI, 1.08-2.69) compared with those with higher medication adherence. LIMITATIONS: Use of self-reported medication adherence rather than pharmacy records. Clinical relevance of detected safety events is unclear.

conclusionsLower medication adherence is associated with adverse safety events in individuals with eGFRs<60 mL/min/1.73 m(2).

Indexed as

Drug MonitoringSelf ReportAgedCohort StudiesCross-Sectional StudiesDrug-Related Side Effects and Adverse ReactionsDrug Therapy, CombinationFemaleGlomerular Filtration RateHumansKidney Function TestsMaleMiddle AgedPatient SafetyPoisson DistributionProspective Studiesadverse safety eventchronic kidney disease (CKD)drug-related problem (DRP)medication adherencepatient safetypolypharmacyReduced kidney functionSafe Kidney Care (SKC) Cohort Studytreatment compliance

Identifiers

PMID25979348
PMCPMC4586079

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.