Evidence map›Paper›PMID 25979270›Full record

SynthesisQJM : monthly journal of the Association of Physicians2016

Prognostic significance of anaemia in patients with heart failure with preserved and reduced ejection fraction: results from the MAGGIC individual patient data meta-analysis.

C Berry, K K Poppe, G D Gamble, N J Earle, J A Ezekowitz, I B Squire, J J V McMurray, F A McAlister, M Komajda, K Swedberg and 6 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in QJM : monthly journal of the Association of Physicians, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  13. Minute ventilation/carbon dioxide production in chronic heart failure.European respiratory review : an official journal of the European Respiratory Society · 2021
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  14. Review
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  16. Article
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  18. Observational
  19. Associations and prognostic significance of diffuse myocardial fibrosis by cardiovascular magnetic resonance in heart failure with preserved ejection fraction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 7 countries.

C BerryFrom the 1 BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
K K PoppeDepartment of Medicine and National Institute for Health Innovation, University of Auckland, New Zealand.
G D GambleDepartment of Medicine and National Institute for Health Innovation, University of Auckland, New Zealand.
N J EarleDepartment of Medicine and National Institute for Health Innovation, University of Auckland, New Zealand.
J A EzekowitzDivision of Cardiology, University of Alberta, Edmonton, Canada.
I B SquireDepartment of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
J J V McMurrayFrom the 1 BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
F A McAlisterDivision of Cardiology, University of Alberta, Edmonton, Canada.
M KomajdaDepartment of Cardiology, University Pierre & Marie Curie (UPMC), Paris, France.
K SwedbergSahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
A P MaggioniANMCO Research Centre, Florence, Italy.
A AhmedDivision of Cardiovascular Disease, University of Alabama at Birmingham and the Veterans Affairs Medical Center, Birmingham, AL, USA.
G A WhalleyFaculty of Social and Health Sciences, Unitec Institute of Technology, Auckland, New Zealand and.
R N DoughtyDepartment of Medicine and National Institute for Health Innovation, University of Auckland, New Zealand.
L TarantiniDepartment of Cardiology, Heart Failure Unit, Ospedale S. Martino, Italy.
MAGGIC Collaborative Group
University of Auckland · NZUniversity of Alberta · CAUniversity of Glasgow · GBAssociazione Nazionale Medici Cardiologi Ospedalieri · ITNIHR Leicester Cardiovascular Biomedical Research Unit · GBOspedale Martini · ITSorbonne Université · FRUnitec Institute of Technology · NZUniversity of Alabama at Birmingham · USUniversity of Gothenburg · SE

Funding

Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

backgroundAnaemia is common among patients with heart failure (HF) and is an important prognostic marker.

aimWe sought to determine the prognostic importance of anaemia in a large multinational pooled dataset of prospectively enrolled HF patients, with the specific aim to determine the prognostic role of anaemia in HF with preserved and reduced ejection fraction (HF-PEF and HF-REF, respectively).

designIndividual person data meta-analysis.

methodsPatients with haemoglobin (Hb) data from the MAGGIC dataset were used. Anaemia was defined as Hb < 120 g/l in women and <130 g/l in men. HF-PEF was defined as EF ≥ 50%; HF-REF was EF < 50%. Cox proportional hazard modelling, with adjustment for clinically relevant variables, was undertaken to investigate factors associated with 3-year all-cause mortality.

resultsThirteen thousand two hundred and ninety-five patients with HF from 19 studies (9887 with HF-REF and 3408 with HF-PEF). The prevalence of anaemia was similar among those with HF-REF and HF-PEF (42.8 and 41.6% respectively). Compared with patients with normal Hb values, those with anaemia were older, were more likely to have diabetes, ischaemic aetiology, New York Heart Association class IV symptoms, lower estimated glomerular filtration rate and were more likely to be taking diuretic and less likely to be taking a beta-blocker. Patients with anaemia had higher all-cause mortality (adjusted hazard ratio [aHR] 1.38, 95% confidence interval [CI] 1.25-1.51), independent of EF group: aHR 1.67 (1.39-1.99) in HF-PEF and aHR 2.49 (2.13-2.90) in HF-REF.

conclusionsAnaemia is an adverse prognostic factor in HF irrespective of EF. The prognostic importance of anaemia was greatest in patients with HF-REF.

Indexed as

AgedAnemiaCause of DeathFemaleHeart FailureHumansMalePrognosisProportional Hazards ModelsProspective StudiesStroke Volume

Identifiers

PMID25979270
PMCPMC5943826
OpenAlexW1860668365

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.