Evidence map›Paper›PMID 25979094›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2015

Preoperative Sleep Disruption and Postoperative Delirium.

Jacqueline M Leung, Laura P Sands, Stacey Newman, Gabriela Meckler, Yimeng Xie, Caryl Gay, Kathryn Lee

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03624595 (Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery), which is not on this map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03624595 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial

TypeinterventionalSponsorDong-Xin WangRan2019 to 2025Enrolled504ConditionsCardiac Surgery, Cardiopulmonary Bypass, Dexmedetomidine, DeliriumArmsDexmedetomidine, Placebo
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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  11. Presurgical Sleep-Wake Disturbance and Postoperative Delirium: A Prospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jacqueline M LeungDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Laura P SandsCenter for Gerontology, Virginia Tech University, Blacksburg, VA.
Stacey NewmanDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Gabriela MecklerDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Yimeng XieCenter for Gerontology, Virginia Tech University, Blacksburg, VA.
Caryl GaySchool of Nursing, University of California, San Francisco, CA.
Kathryn LeeSchool of Nursing, University of California, San Francisco, CA.
University of California, San Francisco · USVirginia Tech · US

Funding

Pathophysiology of postoperative delirium in older patientsR01AG031795 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEUNG, JACQUELINE M · 2009 to 2013
$2.1M
NIA NIH HHS 1R01AG031795-05
6 · The paper itself

Abstract

STUDY

objectivesTo describe preoperative and postoperative sleep disruption and its relationship to postoperative delirium.

designProspective cohort study with 6 time points (3 nights pre-hospitalization and 3 nights post-surgery).

settingUniversity medical center. PATIENTS: The sample consisted of 50 English-speaking patients ≥ 40 years of age scheduled for major non-cardiac surgery, with an anticipated hospital stay ≥ 3 days.

interventionsNone. MEASUREMENTS AND

resultsSleep was measured before and after surgery for a total of 6 days using a wrist actigraph to quantify movement in a continuous fashion. Postoperative delirium was measured by a structured interview using the Confusion Assessment Method. Sleep variables for patients with (n = 7) and without (n = 43) postoperative delirium were compared using the unpaired Student t-tests or χ(2) tests. Repeated measures analysis of variance for the 6 days was used to examine within-subject changes over time and between group differences. The mean age of the patients was 66 ± 11 years (range 43-91 years), and it was not associated with sleep variables or postoperative delirium. The incidence of postoperative delirium observed during any of the 3 postoperative days was 14%. For the 7 patients who subsequently developed postoperative delirium, wake after sleep onset (WASO) as a percentage of total sleep time was significantly higher (44% ± 22%) during the night before surgery compared to the patients who did not subsequently developed delirium (21% ± 20%, p = 0.012). This sleep disruption continued postoperatively, and to a greater extent, for the first 2 nights after surgery. Patients with WASO < 10% did not experience postoperative delirium. Self-reported sleep disturbance did not differ between patients with vs. without postoperative delirium.

conclusionsIn this pilot study of adults over 40 years of age, sleep disruption was more severe before surgery in the patients who experienced postoperative delirium. A future larger study is necessary to confirm our results and determine if poor sleep is associated with delirium in larger samples and what specific sleep problems best predict postoperative delirium in older surgical patients.

Indexed as

Preoperative PeriodActigraphyAdultAgedAged, 80 and overAnalysis of VarianceCohort StudiesComorbidityDeliriumFemaleHumansIncidenceMaleMiddle AgedPilot ProjectsPostoperative Complicationsactigraphypostoperative deliriumpreoperative sleep disruptionsurgery

Identifiers

PMID25979094
PMCPMC4513268
OpenAlexW2338539476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.