ArticleCerebral cortex (New York, N.Y. : 1991)2015
Evidence for Mediodorsal Thalamus and Prefrontal Cortex Interactions during Cognition in Macaques.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
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- Ultra-high Field fMRI Reveals Effect of Ketamine on Vocal Processing in Common Marmosets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Unravelling the nexus of stroke and dementia: Deciphering the role of secondary neurodegeneration in orchestrating cognitive decline.Neuroprotection (Chichester, England) · 2025Review
- Rapid context inference in a thalamocortical model using recurrent neural networks.Nature communications · 2024Article
- Thalamocortical architectures for flexible cognition and efficient learning.Trends in cognitive sciences · 2024Review
- Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia.Cell reports · 2024Article
- Thalamic contributions to psychosis susceptibility: Evidence from co-activation patterns accounting for intra-seed spatial variability (μCAPs).Human brain mapping · 2024Article
- Dementia risk and thalamic nuclei volumetry in healthy midlife adults: the PREVENT Dementia study.Brain communications · 2024Article
- Variable cardiac responses in rhesus macaque monkeys after discrete mediodorsal thalamus manipulations.Scientific reports · 2023Article
- Parallel Pathways Provide Hippocampal Spatial Information to Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortico-thalamocortical interactions for learning, memory and decision-making.The Journal of physiology · 2023Review
- Cerebellar control of thalamocortical circuits for cognitive function: A review of pathways and a proposed mechanism.Frontiers in systems neuroscience · 2023Review
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Macaques fail to develop habit responses during extended training on a reinforcer devaluation task.Behavioral neuroscience · 2022Article
- Professional chess expertise modulates whole brain functional connectivity pattern homogeneity and couplings.Brain imaging and behavior · 2022Article
- Distribution of the Noradrenaline Innervation and Adrenoceptors in the Macaque Monkey Thalamus.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making.Science advances · 2021Article
- Resting-State Functional Connectivity in Mathematical Expertise.Brain sciences · 2021Article
- Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Frequency-dependent gating of feedforward inhibition in thalamofrontal synapses.Molecular brain · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
It is proposed that mediodorsal thalamus contributes to cognition via interactions with prefrontal cortex. However, there is relatively little evidence detailing the interactions between mediodorsal thalamus and prefrontal cortex linked to cognition in primates. This study investigated these interactions during learning, memory, and decision-making tasks in rhesus monkeys using a disconnection lesion approach. Preoperatively, monkeys learned object-in-place scene discriminations embedded within colorful visual backgrounds. Unilateral neurotoxic lesions to magnocellular mediodorsal thalamus (MDmc) impaired the ability to learn new object-in-place scene discriminations. In contrast, unilateral ablations to ventrolateral and orbital prefrontal cortex (PFv+o) left learning intact. A second unilateral MDmc or PFv+o lesion in the contralateral hemisphere to the first operation, causing functional MDmc-PFv+o disconnection across hemispheres, further impaired learning object-in-place scene discriminations, although object discrimination learning remained intact. Adaptive decision-making after reward satiety devaluation was also reduced. These data highlight the functional importance of interactions between MDmc and PFv+o during learning object-in-place scene discriminations and adaptive decision-making but not object discrimination learning. Moreover, learning deficits observed after unilateral removal of MDmc but not PFv+o provide direct behavioral evidence of the MDmc role influencing more widespread regions of the frontal lobes in cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.