ArticleScientific reports2015
A multiplexed device based on tunable nanoshearing for specific detection of multiple protein biomarkers in serum.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Review
- Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection.Sensors (Basel, Switzerland) · 2024Review
- Multiplex electrochemical sensing platforms for the detection of breast cancer biomarkers.Frontiers in medical technology · 2024Review
- 3D Concentric Electrodes-Based Alternating Current Electrohydrodynamics: Design, Simulation, Fabrication, and Potential Applications for Bioassays.Biosensors · 2022Article
- Recent advances in biosensing approaches for point-of-care breast cancer diagnostics: challenges and future prospects.Nanoscale advances · 2021Review
- Point-of-use sweat biosensor to track the endocrine-inflammation relationship for chronic disease monitoring.Future science OA · 2020Article
- Non-Specific Adsorption Reduction Methods in Biosensing.Sensors (Basel, Switzerland) · 2019Review
- Detection of cancer antigens (CA-125) using gold nano particles on interdigitated electrode-based microfluidic biosensor.Nano convergence · 2019Article
- High-Speed Lateral Flow Strategy for a Fast Biosensing with an Improved Selectivity and Binding Affinity.Sensors (Basel, Switzerland) · 2018Article
- Multiplex Immunosensor Arrays for Electrochemical Detection of Cancer Biomarker Proteins.Electroanalysis · 2016Article
- Particle rotational trapping on a floating electrode by rotating induced-charge electroosmosis.Biomicrofluidics · 2016Article
- Alternating current electrohydrodynamics in microsystems: Pushing biomolecules and cells around on surfaces.Biomicrofluidics · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microfluidic flow based multiplexed devices have gained significant promise in detecting biomarkers in complex biological samples. However, to fully exploit their use in bioanalysis, issues such as (i) low sensitivity and (ii) high levels of nonspecific adsorption of non-target species have to be overcome. Herein, we describe a new multiplexed device for the sensitive detection of multiple protein biomarkers in serum by using an alternating current (ac) electrohydrodynamics (ac-EHD) induced surface shear forces based phenomenon referred to as nanoshearing. The tunable nature (via manipulation of ac field) of these nanoshearing forces can alter the capture performance of the device (e.g., improved fluid transport enhances number of sensor-target collisions). This can also selectively displace weakly (nonspecifically) bound molecules from the electrode surface (i.e., fluid shear forces can be tuned to shear away nonspecific species present in biological samples). Using this approach, we achieved sensitive (100 fg mL(-1)) naked eye detection of multiple protein targets spiked in human serum and a 1000-fold enhancement in comparison to hydrodynamic flow based devices for biomarker detection. We believe that this approach could potentially represent a clinical diagnostic tool that can be integrated into resource-limited settings for sensitive detection of target biomarkers using naked eye.
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