Evidence map›Paper›PMID 25978800›Full record

ArticlePediatric research2015

Longitudinal cognitive development of children born to mothers with opioid and polysubstance use.

Egil Nygaard, Vibeke Moe, Kari Slinning, Kristine B Walhovd

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Lactose-free infant formula does not change outcomes of neonatal abstinence syndrome (NAS): a randomized clinical trial.Journal of perinatology : official journal of the California Perinatal Association · 2021
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Egil Nygaard1] Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway [2] Center for Child and Adolescent Mental Health, Eastern and Southern Norway (RBUP), Oslo, Norway.
Vibeke Moe1] Center for Child and Adolescent Mental Health, Eastern and Southern Norway (RBUP), Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
Kari Slinning1] Center for Child and Adolescent Mental Health, Eastern and Southern Norway (RBUP), Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
Kristine B Walhovd1] Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway [2] Department of Physical Medicine and Rehabilition, Unit of Neuropsychology, Oslo University Hospital, Oslo, Norway.
University of Oslo · NOCenter for Child and Adolescent Mental Health, Eastern and Southern Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies indicate an increased risk for neuropsychological difficulties in young children prenatally exposed to opioids and polysubstances, but longitudinal information is scarce. The present longitudinal study investigated whether these waned, persisted, or increased over time.

methodsThe cognitive functioning of 72 children with prenatal opioid and polysubstance exposure and 58 children without any established prenatal risk was assessed at 1, 2, 3, 4½, and 8½ y.

resultsThe exposed boys had significantly and stably lower levels of cognitive functioning than the control group, whereas there were increasing differences over time for the girls. The exposed group had significantly lower IQ scores than the control group on Wechsler Intelligence Scale for Children--Revised at 8½ y after controlling for earlier cognitive abilities, and for children who were permanently placed in adoptive/foster homes before 1 y of age and whose mothers used heroin as their main drug during pregnancy (B = 17.04, 95% CI 8.69-25.38, P < 0.001).

conclusionWhile effects of prenatal substance exposure cannot be isolated, group effects on cognition rather increased than waned over time, even in adoptive/foster children with minimal postnatal risk.

Indexed as

Maternal ExposureAnalgesics, OpioidChildChild DevelopmentChild, PreschoolCognitionDevelopmental DisabilitiesFemaleHumansInfantIntelligence TestsLongitudinal StudiesMaleNeuropsychological TestsPregnancyPregnancy ComplicationsAnalgesics, Opioid

Identifiers

PMID25978800
PMCPMC4539602
OpenAlexW2263346783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.