Evidence map›Paper›PMID 25978799›Full record

ArticleEnvironmental health perspectives2015

The NIEHS Superfund Research Program: 25 Years of Translational Research for Public Health.

Philip J Landrigan, Robert O Wright, Jose F Cordero, David L Eaton, Bernard D Goldstein, Bernhard Hennig, Raina M Maier, David M Ozonoff, Martyn T Smith, Robert H Tukey

Open access · diamondAbstract readHistorical Article
In one paragraph

Article in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Hazardous waste and health impact: a systematic review of the scientific literature.Environmental health : a global access science source · 2017
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Protecting Children from Toxic Waste: Data-Usability Evaluation Can Deter Flawed Cleanup.International journal of environmental research and public health · 2020
    Article
  11. Article
  12. The Environmental Protection Agency's Use of Community Involvement to Engage Communities at Superfund Sites.International journal of environmental research and public health · 2019
    Article
  13. Working with Institutional Stakeholders: Propositions for Alternative Approaches to Community Engagement.International journal of environmental research and public health · 2019
    Article
  14. Themes Across New Directions in Community Engagement.International journal of environmental research and public health · 2019
    Review
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Philip J LandriganIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Robert O Wright
Jose F Cordero
David L Eaton
Bernard D Goldstein
Bernhard Hennig
Raina M Maier
David M Ozonoff
Martyn T Smith
Robert H Tukey
Icahn School of Medicine at Mount Sinai · USBerkeley Public Health Division · USBoston University · USUniversity of Arizona · USUniversity of California San Diego · USUniversity of Kentucky · USUniversity of Pittsburgh · USUniversity of Puerto Rico System · PRUniversity of Washington · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
TRANSPORT OF TRACE METALS IN A POLLUTED AQUIFERP42ES004940 · NIEHS · UNIVERSITY OF ARIZONA · PI Jon D Chorover · 1990 to 2026
$68.1M
Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI ALSHAWABKEH, AKRAM N · 2010 to 2024
$38.6M
NIEHS NIH HHS P42 ES004940NIEHS NIH HHS P42 ES010337NIEHS NIH HHS P42 ES017198
6 · The paper itself

Abstract

backgroundThe Superfund Research Program (SRP) is an academically based, multidisciplinary, translational research program that for 25 years has sought scientific solutions to health and environmental problems associated with hazardous waste sites. SRP is coordinated by the National Institute of Environmental Health Sciences (NIEHS). It supports multi-project grants, undergraduate and postdoctoral training programs, individual research grants, and Small Business Innovation Research (SBIR) and Technology Transfer Research (STTR) grants.

resultsSRP has had many successes: discovery of arsenic's toxicity to the developing human central nervous system; documentation of benzene toxicity to hematologic progenitor cells in human bone marrow; development of novel analytic techniques such as the luciferase expression assay and laser fragmentation fluorescence spectroscopy; demonstration that PCBs can cause developmental neurotoxicity at low levels and alter the genomic characteristics of sentinel animals; elucidation of the neurodevelopmental toxicity of organophosphate insecticides; documentation of links between antimicrobial agents and alterations in hormone response; discovery of biological mechanisms through which environmental chemicals may contribute to obesity, atherosclerosis, diabetes, and cancer; tracking the health and environmental effects of the attacks on the World Trade Center and Hurricane Katrina; and development of novel biological and engineering techniques to facilitate more efficient and lower-cost remediation of hazardous waste sites.

conclusionSRP must continue to address the legacy of hazardous waste in the United States, respond to new issues caused by rapid advances in technology, and train the next generation of leaders in environmental health science while recognizing that most of the world's worst toxic hot spots are now located in low- and middle-income countries.

Indexed as

Environmental HealthHazardous WasteHazardous Waste SitesHistory, 20th CenturyHistory, 21st CenturyHumansNational Institute of Environmental Health Sciences (U.S.)Public HealthTranslational Research, BiomedicalUnited StatesHazardous Waste

Identifiers

PMID25978799
PMCPMC4590764
OpenAlexW323798533

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.