Evidence map›Paper›PMID 25978772›Full record

ArticlePloS one2015

Broadband onset inhibition can suppress spectral splatter in the auditory brainstem.

Martin J Spencer, David A X Nayagam, Janine C Clarey, Antonio G Paolini, Hamish Meffin, Anthony N Burkitt, David B Grayden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Martin J SpencerNeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; National ICT Australia, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; Centre for Neural Engineering, University of Melbourne, Melbourne, Australia.
David A X NayagamBionics Institute, Melbourne, Australia; Department of Pathology, University of Melbourne, Melbourne, Australia.
Janine C ClareyBionics Institute, Melbourne, Australia.
Antonio G PaoliniHealth Innovations Research Institute, RMIT University, Melbourne, Australia.
Hamish MeffinNational ICT Australia, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; NeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; Centre for Neural Engineering, University of Melbourne, Melbourne, Australia.
Anthony N BurkittNeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; National ICT Australia, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; Centre for Neural Engineering, University of Melbourne, Melbourne, Australia; Bionics Institute, Melbourne, Australia.
David B GraydenNeuroEngineering Laboratory, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; National ICT Australia, Department of Electrical and Electronic Engineering, University of Melbourne, Melbourne, Australia; Centre for Neural Engineering, University of Melbourne, Melbourne, Australia; Bionics Institute, Melbourne, Australia.
Bionics Institute · AUData61 · AURMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo intracellular responses to auditory stimuli revealed that, in a particular population of cells of the ventral nucleus of the lateral lemniscus (VNLL) of rats, fast inhibition occurred before the first action potential. These experimental data were used to constrain a leaky integrate-and-fire (LIF) model of the neurons in this circuit. The post-synaptic potentials of the VNLL cell population were characterized using a method of triggered averaging. Analysis suggested that these inhibited VNLL cells produce action potentials in response to a particular magnitude of the rate of change of their membrane potential. The LIF model was modified to incorporate the VNLL cells' distinctive action potential production mechanism. The model was used to explore the response of the population of VNLL cells to simple speech-like sounds. These sounds consisted of a simple tone modulated by a saw tooth with exponential decays, similar to glottal pulses that are the repeated impulses seen in vocalizations. It was found that the harmonic component of the sound was enhanced in the VNLL cell population when compared to a population of auditory nerve fibers. This was because the broadband onset noise, also termed spectral splatter, was suppressed by the fast onset inhibition. This mechanism has the potential to greatly improve the clarity of the representation of the harmonic content of certain kinds of natural sounds.

Indexed as

Acoustic StimulationAction PotentialsAnimalsAuditory PathwaysBrain StemElectrophysiologyMaleModels, BiologicalNeuronsRatsRats, WistarSoundSynaptic Potentials

Identifiers

PMID25978772
PMCPMC4433210
OpenAlexW2213844946

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.