Evidence map›Paper›PMID 25978526›Full record

SynthesisEnvironmental health perspectives2016

Global Association of Cold Spells and Adverse Health Effects: A Systematic Review and Meta-Analysis.

Niilo R I Ryti, Yuming Guo, Jouni J K Jaakkola

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of Short-Term Exposure to Extreme Temperatures on Mortality: A Multi-City Study in Belgium.International journal of environmental research and public health · 2022
    Pooled it
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  6. Lack of guidelines for cold exposure among vulnerable outdoor workers.International journal of circumpolar health · 2026
    Review
  7. Heat- and Cold-Associated Mortality in Germany, 2000-2023.Deutsches Arzteblatt international · 2026
    Observational
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  18. Observational
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Niilo R I RytiCenter for Environmental and Respiratory Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
Yuming Guo
Jouni J K Jaakkola

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is substantial evidence that mortality increases in low temperatures. Less is known about the role of prolonged cold periods denoted as cold spells.

objectiveWe conducted the first systematic review and meta-analysis to summarize the evidence on the adverse health effects of cold spells in varying climates. DATA SOURCES AND EXTRACTION: Four databases (Ovid Medline, PubMed, Scopus, Web of Science) were searched for all years and languages available. "Cold spell" was defined as an event below a temperature threshold lasting for a minimum duration of 2 days. Of 1,527 identified articles, 26 satisfied our eligibility criteria for the systematic review, and 9 were eligible for meta-analyses. The articles were grouped by the three main study questions into Overall-effect Group, Added-effect Group, and Temperature-change-effect Group. DATA SYNTHESIS: Based on random-effects models in the meta-analyses, cold spells were associated with increased mortality from all or all nonaccidental causes (summary rate ratio = 1.10; 95% CI: 1.04, 1.17 based on 9 estimates from five studies), cardiovascular diseases (1.11; 95% CI: 1.03, 1.19; 12 estimates from eight studies), and respiratory diseases (1.21; 95% CI: 0.97, 1.51; 8 estimates from four studies). Estimated associations were stronger for people ≥ 65 years of age (1.06; 95% CI: 1.00, 1.12) than for people 0-64 years of age (1.01; 95% CI: 1.00, 1.03). Study-specific effect estimates from a limited number of studies suggested an increased morbidity related to cold spells, but it was not possible to quantitatively summarize the evidence.

conclusionsCold spells are associated with increased mortality rates in populations around the world. The body of evidence suggests that cold spells also have other adverse health effects. There was substantial heterogeneity among the studies, which should be taken into account in the interpretation of the results. CITATION: Ryti NR, Guo Y, Jaakkola JJ. 2016. Global association of cold spells and adverse health effects: a systematic review and meta-analysis. Environ Health Perspect 124:12-22; http://dx.doi.org/10.1289/ehp.1408104.

Indexed as

Cold TemperatureCardiovascular DiseasesDatabases, FactualHumansModels, TheoreticalPublic Health

Identifiers

PMID25978526
PMCPMC4710591

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.