ArticlePloS one2015
bHLH106 Integrates Functions of Multiple Genes through Their G-Box to Confer Salt Tolerance on Arabidopsis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
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- Identification and characterization of the DREB family in Chinese yam and functional study of DoDREB28 under drought stress.BMC plant biology · 2026Article
- Global analysis of soybean bZIP gene family under stress and identification of salt-stress-responsive candidate genes.Frontiers in plant science · 2026Article
- Genome-wide association studies reveal genetic diversity and regulatory loci underlying dwarfing traits in banana.Journal of integrative plant biology · 2025Article
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- Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Frontiers in plant science · 2024Article
- Comparative transcriptomic and proteomic analyses of two salt-tolerant alfalfa (Frontiers in plant science · 2024Article
- Tartary Buckwheat (International journal of molecular sciences · 2023Article
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2023Article
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- Roles of S-Adenosylmethionine and Its Derivatives in Salt Tolerance of Cotton.International journal of molecular sciences · 2023Review
- Transcriptional and Post-Translational Regulation of Plant bHLH Transcription Factors during the Response to Environmental Stresses.Plants (Basel, Switzerland) · 2023Review
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- Genome-wide identification of bHLH transcription factors and their response to salt stress inFrontiers in plant science · 2023Article
- Insights to the superoxide dismutase genes and its roles in3 Biotech · 2022Article
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8 authors.
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Abstract
An activation-tagging methodology was applied to dedifferentiated calli of Arabidopsis to identify new genes involved in salt tolerance. This identified salt tolerant callus 8 (stc8) as a gene encoding the basic helix-loop-helix transcription factor bHLH106. bHLH106-knockout (KO) lines were more sensitive to NaCl, KCl, LiCl, ABA, and low temperatures than the wild-type. Back-transformation of the KO line rescued its phenotype, and over-expression (OX) of bHLH106 in differentiated plants exhibited tolerance to NaCl. Green fluorescent protein (GFP) fused with bHLH106 revealed that it was localized to the nucleus. Prepared bHLH106 protein was subjected to electrophoresis mobility shift assays against E-box sequences (5'-CANNTG-3'). The G-box sequence 5'-CACGTG-3' had the strongest interaction with bHLH106. bHLH106-OX lines were transcriptomically analyzed, and resultant up- and down-regulated genes selected on the criterion of presence of a G-box sequence. There were 198 genes positively regulated by bHLH106 and 36 genes negatively regulated; these genes possessed one or more G-box sequences in their promoter regions. Many of these genes are known to be involved in abiotic stress response. It is concluded that bHLH106 locates at a branching point in the abiotic stress response network by interacting directly to the G-box in genes conferring salt tolerance on plants.
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