ArticlePloS one2015
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- Probiotics in Autoimmune Disease: Strain-specific Mechanisms and Therapeutic Perspectives.Clinical reviews in allergy & immunology · 2026Review
- Enterococcus faecalis NBRC 100481 Protects the Intestinal Barrier via α-catenin/HMP-1 in Caenorhabditis elegans.Probiotics and antimicrobial proteins · 2026Article
- Enterococcus faecalis KU-EF-004 enhances efficacy of anti-CTLA-4 immunotherapy for colorectal cancer via dendritic cell activation and gut microbiota modulation.BMC immunology · 2026Article
- Review
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- Assessment of the Safety and Probiotic Properties ofMicroorganisms · 2024Article
- The novel immunobioticFrontiers in immunology · 2023Article
- Obesity aggravates contact hypersensitivity reaction in mice.Contact dermatitis · 2022Article
- Combined Transcriptomic and Protein Array Cytokine Profiling of Human Stem Cells from Dental Apical Papilla Modulated by Oral Bacteria.International journal of molecular sciences · 2022Article
- Norepinephrine and Serotonin Can Modulate the Behavior of the ProbioticMicroorganisms · 2022Article
- Lipoteichoic Acid fromNutrients · 2022Article
- Antiviral Effects and Underlying Mechanisms of Probiotics as Promising Antivirals.Frontiers in cellular and infection microbiology · 2022Review
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- Commercial microbiota test revealed differences in the composition of intestinal microorganisms between children with autism spectrum disorders and neurotypical peers.Scientific reports · 2021Article
- Safety and metabolic characteristics of 17 Enterococcus faecium isolates.Archives of microbiology · 2021Article
- Bacteriocin-Like Inhibitory Substance (BLIS) Activity of Enterococcus faecium DB1 Against Biofilm Formation by Clostridium perfringens.Probiotics and antimicrobial proteins · 2021Article
- The post-hematopoietic cell transplantation microbiome: relationships with transplant outcome and potential therapeutic targets.Haematologica · 2021Review
- Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota.Signal transduction and targeted therapy · 2021Article
- Immunostimulatory Effects of LiveNutrients · 2020Article
- Evaluation of commercial veterinary probiotics containing enterococci for transferrable vancomycin resistance genes.BMC research notes · 2020Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probiotics can modulate the immune system, conferring beneficial effects on the host. Understanding how these microorganisms contribute to improve the health status is still a challenge. Previously, we have demonstrated that Enterococcus faecalis CECT7121 implants itself and persists in the murine gastrointestinal tract, and enhances and skews the profile of cytokines towards the Th1 phenotype in several biological models. Given the importance of dendritic cells (DCs) in the orchestration of immunity, the aim of this work was to elucidate the influence of E. faecalis CECT7121 on DCs and the outcome of the immune responses. In this work we show that E. faecalis CECT7121 induces a strong dose-dependent activation of DCs and secretion of high levels of IL-12, IL-6, TNFα, and IL-10. This stimulation is dependent on TLR signaling, and skews the activation of T cells towards the production of IFNγ. The influence of this activation in the establishment of Th responses in vivo shows the accumulation of specific IFNγ-producing cells. Our findings indicate that the activation exerted by E. faecalis CECT7121 on DCs and its consequence on the cellular adaptive immune response may have broad therapeutic implications in immunomodulation.
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