ArticleCritical care medicine2015
Dichotomous "Good Outcome" Indicates Mobility More Than Cognitive or Social Quality of Life.
Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Can we trust computers to assess the cognition of stroke patients? A systematic review.Frontiers in neurology · 2023Pooled it
- Prophylactic Antiseizure Medication in Patients with Lobar Intracerebral Hemorrhage.Neurocritical care · 2026Observational
- Timing of neuroprognostication in the ICU.Current opinion in critical care · 2025Review
- Outcomes Measures in Subarachnoid Hemorrhage Research.Translational stroke research · 2025Review
- Delirium and Its Associations with Critical Care Utilizations and Outcomes at the Time of Hospital Discharge in Patients with Acute Brain Injury.Medicina (Kaunas, Lithuania) · 2024Article
- Predicting Early Seizures After Intracerebral Hemorrhage with Machine Learning.Neurocritical care · 2022Article
- Clusters Across Multiple Domains of Health-Related Quality of Life Reveal Complex Patient Outcomes After Subarachnoid Hemorrhage.Critical care explorations · 2021Article
- Prognostication after intracerebral hemorrhage: a review.Neurological research and practice · 2021Review
- Identifying Modifiable Predictors of Patient Outcomes After Intracerebral Hemorrhage with Machine Learning.Neurocritical care · 2021Article
- Effects of Hypoxic and Ischemic Clinical Conditions on the Outcomes of Acute Ischemic Stroke Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs.Frontiers in neurology · 2020Article
- Improving the Accuracy of Scores to Predict Gastrostomy after Intracerebral Hemorrhage with Machine Learning.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2018Article
- Endovascular treatment of acute ischaemic stroke under conscious sedation: Predictors of poor outcomes.Indian journal of anaesthesia · 2018Article
- Depressive symptom prevalence after intracerebral hemorrhage: a multi-center study.Journal of patient-reported outcomes · 2018Article
- Fever Burden and Health-Related Quality of Life After Intracerebral Hemorrhage.Neurocritical care · 2018Observational
- Article
- Refining Prognosis for Intracerebral Hemorrhage by Early Reassessment.Cerebrovascular diseases (Basel, Switzerland) · 2017Observational
- Article
- Neuro-Intensivists as Effective Resource Managers. No, Really.Neurocritical care · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWorthwhile interventions for intracerebral hemorrhage or subarachnoid hemorrhage generally hinge on whether they improve the odds of good outcome. Although good outcome is correlated with mobility, correlations with other domains of health-related quality of life, such as cognitive function and social functioning, are not well described. We tested the hypothesis that good outcome is more closely associated with mobility than other domains.
designWe defined "good outcome" as 0 through 3 (independent ambulation or better) versus 4 through 5 (dependent) on the modified Rankin Scale at 1, 3, and 12 months. We simultaneously assessed the modified Rankin Scale and health-related quality of life using web-based computer adaptive testing in the domains of mobility, cognitive function (executive function and general concerns), and satisfaction with social roles and activities. We compared the area under the curve between different health-related quality of life domains.
settingNeurologic ICU with web-based follow-up. PATIENTS: One hundred fourteen patients with subarachnoid hemorrhage or intracerebral hemorrhage.
interventionsNone. MEASUREMENT AND MAIN
resultsWe longitudinally followed 114 survivors with data at 1 month, 62 patients at 3 months, and 58 patients at 12 months. At 1 month, area under the curve was highest for mobility (0.957; 95% CI, 0.904-0.98), higher than cognitive function-general concerns (0.819; 95% CI, 0.715-0.888; p = 0.003 compared with mobility), satisfaction with social roles and activities (0.85; 95% CI, 0.753-0.911; p = 0.01 compared with mobility), and cognitive function-executive function (0.879; 95% CI, 0.782-0.935; p = 0.058 compared with mobility). Optimal specificity and sensitivity for receiver operating characteristic analysis were approximately 1.5 SD below the U.S. population mean.
conclusionsHealth-related quality of life assessments reliably distinguished between good and poor outcomes as determined by the modified Rankin Scale. Good outcome indicated health-related quality of life about 1.5 SD below the U.S. population mean. Associations were weaker for cognitive function and social function than mobility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.