Evidence map›Paper›PMID 25978159›Full record

ArticleCritical care medicine2015

Combination Therapy for Extreme Drug-Resistant Acinetobacter baumannii: Ready for Prime Time?

Brad Spellberg, Robert A Bonomo

Open access · greenAbstract readEditorialComment
In one paragraph

Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
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  6. Antibiotic-potentiating efficacy ofFrontiers in pharmacology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
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  18. Frontiers in pharmacology · 2022
    Article
  19. Article
  20. Insights intoAntibiotics (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Brad SpellbergDivision of Infectious Diseases, Keck School of Medicine at USC and the Los Angeles County-USC Medical Center, Los Angeles, CA Department of Medicine, Department of Pharmacology, Department of Molecular Biology and Microbiology, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH.
Robert A Bonomo
Case Western Reserve University · USLAC+USC Medical Center · US

Funding

Humanized Monoclonal Antibodies to Treat Acinetobacter InfectionsR41AI106375 · NIAID · BIOLOGICAL ANTI-INFECTIVE MEDICINES, LLC · PI SPELLBERG, BRAD J · 2013 to 2014
$574k
Acinetobacter virulence and host innunopathogenesisR21AI101750 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2013 to 2014
$434k
Monoclonal antibody passive vaccination to treat XDR Acinetobacter infectionsR56AI104751 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2014 to 2014
$434k
NIAID NIH HHS R21 AI101750NIAID NIH HHS R41 AI106375NIAID NIH HHS R56 AI104751
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acinetobacter InfectionsAnti-Bacterial AgentsCarbapenemsColistinFemaleHumansMaleMinocyclineAnti-Bacterial AgentsCarbapenemsColistinMinocycline

Identifiers

PMID25978159
PMCPMC4620434
OpenAlexW2317789273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.