Evidence map›Paper›PMID 25977929›Full record

ArticleJournal of diabetes research2015

The impact of abnormal glucose tolerance and obesity on fetal growth.

Erin Graves, David J Hill, Susan Evers, Kristine Van Aarsen, Brie Yama, Su Yuan, M Karen Campbell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erin GravesDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada N6A 5C1.ORCID 0000-0002-1518-0564
David J HillDepartment of Physiology and Pharmacology, Western University, London, ON, Canada N6A 5C1 ; Lawson Health Research Institute, London, ON, Canada N6C 2R5.
Susan EversDepartment of Family Relations and Applied Nutrition, Guelph, ON, Canada N1G 2W1.
Kristine Van AarsenDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada N6A 5C1.
Brie YamaDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada N6A 5C1.
Su YuanDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada N6A 5C1.
M Karen CampbellDepartment of Epidemiology and Biostatistics, Western University, London, ON, Canada N6A 5C1 ; Lawson Health Research Institute, London, ON, Canada N6C 2R5 ; Department of Obstetrics and Gynaecology, Western University, London, ON, Canada N6H 5W9 ; Department of Paediatrics, Western University, London, ON, Canada N6C 2R6 ; Children's Health Research Institute, London, ON, Canada N6C 2V5.

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

objectiveFactors linked with insulin resistance were examined for their association with large-for-gestational-age (LGA) infant birth weight and gestational diabetes. STUDY

designData came from a longitudinal cohort study of 2,305 subjects without overt diabetes, analyzed using multinomial logistic and linear regression.

resultsHigh maternal BMI (OR = 1.53 (1.11, 2.12)), height (1.98 (1.62, 2.42)), antidepressant use (1.71 (1.20, 2.44)), pregnancy weight-gain exceeding 40 pounds (1.79 (1.25, 2.57)), and high blood sugar (2.68, (1.53, 5.27)) were all positively associated with LGA birth. Strikingly, the difference in risk from diagnosed and treated gestational diabetes compared to women with a single abnormal glucose tolerance test (but no diagnosis of gestational diabetes) was significant (OR = 0.65, p = 0.12 versus OR = 2.84, p < 0.01). When weight/length ratio was used instead, different factors were found to be significant. BMI and pregnancy weight-gain were found to influence the development of gestational diabetes, through an additive interaction.

conclusionsHigh prepregnancy BM, height, antidepressant use, pregnancy weight-gain exceeding 40 pounds, and high blood sugar were associated with LGA birth, but not necessarily infant weight/length ratio. An additive interaction between BMI and pregnancy weight-gain influenced gestational diabetes development.

Indexed as

AdultBirth WeightBody Mass IndexDiabetes, GestationalFemaleFetal DevelopmentGestational AgeGlucose IntoleranceHumansInfantInfant, NewbornLongitudinal StudiesObesityPregnancy

Identifiers

PMID25977929
PMCPMC4421033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.