Evidence map›Paper›PMID 25977920›Full record

ArticleBioMed research international2015

Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.

Shaobo Yao, Kongzhen Hu, Ganghua Tang, Siyuan Gao, Caihua Tang, Baoguo Yao, Dahong Nie, Ting Sun, Shende Jiang

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Molecular imaging-its current role in cancer.QJM : monthly journal of the Association of Physicians · 2016
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shaobo YaoDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Kongzhen HuDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Ganghua TangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0003-2639-0388
Siyuan GaoDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Caihua TangDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Baoguo YaoDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Dahong NieDepartment of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Ting SunDepartment of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Shende JiangSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Sun Yat-sen University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.

Indexed as

AnimalsApoptosisCell Line, TumorChromatography, High Pressure LiquidCyclophosphamideFemaleHumansInjections, IntravenousIn Situ Nick-End LabelingJurkat CellsMethylmalonic AcidMice, NudeMolecular ImagingPositron-Emission TomographyTissue Distribution2-(3-fluoropropyl)-2-methylmalonic acidCyclophosphamideMethylmalonic Acid

Identifiers

PMID25977920
PMCPMC4420799
OpenAlexW1965067545

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.