Evidence map›Paper›PMID 25977812›Full record

ArticleScientific data2015

High-resolution gene expression data from blastoderm embryos of the scuttle fly Megaselia abdita.

Karl R Wotton, Eva Jiménez-Guri, Anton Crombach, Damjan Cicin-Sain, Johannes Jaeger

Abstract readDataset
In one paragraph

Article in Scientific data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karl R WottonEMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG) , 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF) , 08002 Barcelona, Spain.ORCID 0000-0002-8672-9948
Eva Jiménez-GuriEMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG) , 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF) , 08002 Barcelona, Spain.
Anton CrombachEMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG) , 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF) , 08002 Barcelona, Spain.
Damjan Cicin-SainEMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG) , 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF) , 08002 Barcelona, Spain.
Johannes JaegerEMBL/CRG Research Unit in Systems Biology, Centre for Genomic Regulation (CRG) , 08003 Barcelona, Spain ; Universitat Pompeu Fabra (UPF) , 08002 Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gap genes are involved in segment determination during early development in dipteran insects (flies, midges, and mosquitoes). We carried out a systematic quantitative comparative analysis of the gap gene network across different dipteran species. Our work provides mechanistic insights into the evolution of this pattern-forming network. As a central component of our project, we created a high-resolution quantitative spatio-temporal data set of gap and maternal co-ordinate gene expression in the blastoderm embryo of the non-drosophilid scuttle fly, Megaselia abdita. Our data include expression patterns in both wild-type and RNAi-treated embryos. The data-covering 10 genes, 10 time points, and over 1,000 individual embryos-consist of original embryo images, quantified expression profiles, extracted positions of expression boundaries, and integrated expression patterns, plus metadata and intermediate processing steps. These data provide a valuable resource for researchers interested in the comparative study of gene regulatory networks and pattern formation, an essential step towards a more quantitative and mechanistic understanding of developmental evolution.

Indexed as

BlastodermDipteraGenes, InsectAnimalsGene ExpressionGene Expression Regulation, Developmental

Identifiers

PMID25977812
PMCPMC4423355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.