Evidence map›Paper›PMID 25977809›Full record

ArticleScientific data2015

Human olfactory receptor responses to odorants.

Joel D Mainland, Yun R Li, Ting Zhou, Wen Ling L Liu, Hiroaki Matsunami

Open access · goldAbstract readDataset
In one paragraph

Article in Scientific data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 1 synthesis or guideline pooled it, 157 citations in OpenAlex.

  1. Microbial volatile organic compounds and olfactory receptors in wound malodor.Frontiers in cellular and infection microbiology · 2026
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Olfactory receptors and human diseases.Cell and tissue research · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Harnessing Odorant Receptor Activation to Suppress Real Malodor.International journal of molecular sciences · 2025
    Article
  17. Review
  18. Bio-Inspired Neuromorphic Sensory Systems from Intelligent Perception to Nervetronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joel D MainlandMonell Chemical Senses Center , 3500 Market Street, Philadelphia, Pennsylvania 19104, USA ; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA ; Department of Neuroscience, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-5056-4598
Yun R LiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA.ORCID 0000-0002-8077-4975
Ting ZhouDepartment of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA.
Wen Ling L LiuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA.
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA ; Department of Neurobiology and Duke Institute for Brain Sciences, Duke University Medical Center , Research Drive, Durham, North Carolina 27710, USA.
Duke University · USMonell Chemical Senses Center · US

Funding

Molecular Mechanisms Underlying Odorant RecognitionR01DC005782 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2002 to 2012
$3.5M
Perceptual effects of genetic variation in human odorant receptorsR01DC013339 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MAINLAND, JOEL D · 2013 to 2017
$1.9M
Modulation of Odorant Receptor FunctionR01DC012095 · NIDCD · DUKE UNIVERSITY · PI MATSUNAMI, HIROAKI · 2012 to 2016
$1.8M
Variability in the human odorant receptor repertoireR03DC011373 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MAINLAND, JOEL D · 2011 to 2013
$476k
The Genetic Basis of Specific AnosmiaF32DC008932 · NIDCD · DUKE UNIVERSITY · PI MAINLAND, JOEL D · 2007 to 2009
$162k
NIDCD NIH HHS F32 DC008932NIDCD NIH HHS R01 DC005782NIDCD NIH HHS R01 DC012095NIDCD NIH HHS R01 DC013339NIDCD NIH HHS R03 DC011373
6 · The paper itself

Abstract

Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.

Indexed as

LigandsReceptors, OdorantBiological AssayHumansLuciferasesOdorantsLigandsLuciferasesReceptors, Odorant

Identifiers

PMID25977809
PMCPMC4412152
OpenAlexW2267570377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.