ArticleScientific data2014
Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.
Article in Scientific data, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Data-driven synapse classification reveals a logic of glutamate receptor diversity.bioRxiv : the preprint server for biology · 2025Article
- An open-source, end-to-end workflow for multidimensional photoemission spectroscopy.Scientific data · 2020Article
- DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images.PLoS computational biology · 2019Article
- A Computational Synaptic Antibody Characterization Tool for Array Tomography.Frontiers in neuroanatomy · 2018Article
- Probabilistic fluorescence-based synapse detection.PLoS computational biology · 2017Article
- Array tomography of physiologically-characterized CNS synapses.Journal of neuroscience methods · 2016Article
- Ctrl alt share.Scientific data · 2015Article
- Synaptic molecular imaging in spared and deprived columns of mouse barrel cortex with array tomography.Scientific data · 2014Article
Corrections and comments
- Commented on byCtrl alt share.2015
Authors and funding
5 authors.
Funding
Abstract
A major question in neuroscience is how diverse subsets of synaptic connections in neural circuits are affected by experience dependent plasticity to form the basis for behavioral learning and memory. Differences in protein expression patterns at individual synapses could constitute a key to understanding both synaptic diversity and the effects of plasticity at different synapse populations. Our approach to this question leverages the immunohistochemical multiplexing capability of array tomography (ATomo) and the columnar organization of mouse barrel cortex to create a dataset comprising high resolution volumetric images of spared and deprived cortical whisker barrels stained for over a dozen synaptic molecules each. These dataset has been made available through the Open Connectome Project for interactive online viewing, and may also be downloaded for offline analysis using web, Matlab, and other interfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.