Evidence map›Paper›PMID 25977763›Full record

ArticleScientific data2014

miRNA expression atlas in male rat.

Keiichi Minami, Takeki Uehara, Yuji Morikawa, Ko Omura, Masayuki Kanki, Akira Horinouchi, Atsushi Ono, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani

Abstract readDataset
In one paragraph

Article in Scientific data, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trauma-induced alterations in bone marrow exosome microRNA profiles.The journal of trauma and acute care surgery · 2026
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  10. CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Keiichi MinamiExploratory Research Laboratories, Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd. , 17-2 Wadai, Tsukuba-shi, Ibaraki 300-4247, Japan.
Takeki UeharaDrug Developmental Research Laboratories, Shionogi & Co., Ltd. , 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan ; Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan.
Yuji MorikawaDrug Developmental Research Laboratories, Shionogi & Co., Ltd. , 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan ; Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan.
Ko OmuraDrug Safety Research Laboratories, Astellas Pharma Inc. , 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
Masayuki KankiDrug Safety Research Laboratories, Astellas Pharma Inc. , 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
Akira HorinouchiChemistry, Manufacturing and Controls Center, Takeda Pharmaceutical Company Limited , 17-85, Jusohonmachi 2-chome, Yodogawaku, Osaka 532-8686, Japan.
Atsushi OnoToxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan ; National Institute of Health Sciences , 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Hiroshi YamadaToxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan.
Yasuo OhnoNational Institute of Health Sciences , 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Tetsuro UrushidaniToxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan ; Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo , Kyotanabe, Kyoto 610-0395, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small (~22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.

Indexed as

Gene ExpressionRatsAnimalsGene Expression ProfilingGenomeMaleMicroRNAsOrgan SpecificityMicroRNAs

Identifiers

PMID25977763
PMCPMC4322570

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.