Evidence map›Paper›PMID 25977694›Full record

ArticleHepatitis monthly2015

Economic burden of hepatitis B virus-related diseases: evidence from iran.

Khosro Keshavarz, Abbas Kebriaeezadeh, Seyed Moayed Alavian, Ali Akbari Sari, Farid Abedin Dorkoosh, Maryam Keshvari, Seyed Ali Malekhosseini, Saman Nikeghbalian, Shekoufeh Nikfar

Abstract read
In one paragraph

Article in Hepatitis monthly, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Acupuncture for chronic hepatitis B.The Cochrane database of systematic reviews · 2019
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. The economic burden of bipolar disorder: a case study in Southern Iran.Cost effectiveness and resource allocation : C/E · 2024
    Article
  7. Review
  8. Economic burden of breast cancer: a case of Southern Iran.Cost effectiveness and resource allocation : C/E · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Protein-protein interactions of human viruses.Seminars in cell & developmental biology · 2020
    Review
  15. Article
  16. Article
  17. Comparative study on guidelines in determining HBV phases in Iranian patients.Gastroenterology and hepatology from bed to bench · 2019
    Article
  18. A case-control study of risk factors for hepatitis B infection: A regional report among Isfahanian adults.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khosro KeshavarzDepartment of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran ; Health Human Resource Research Center, School of Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Abbas KebriaeezadehDepartment of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran.
Seyed Moayed AlavianBaqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Ali Akbari SariDepartment of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran ; Department of Health Management and Economics, Tehran University of Medical Sciences, Tehran, IR Iran.
Farid Abedin DorkooshDepartment of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran.
Maryam KeshvariBlood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Iranian Blood Transfusion Organization, Tehran, IR Iran.
Seyed Ali MalekhosseiniShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Saman NikeghbalianShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran.
Shekoufeh NikfarDepartment of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IR Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis B infection is still the main cause of chronic liver disease in Iran, which is associated with significant economic and social costs.

objectivesThis study aimed to estimate the financial burden caused by CHB infection and its complications in Iran. PATIENTS AND

methodsPrevalence-based and bottom-up approaches were used to collect the data. Data on direct medical costs were extracted from outpatient medical records in a referral gastroenterology and hepatology research center, inpatient medical records in several major hospitals in Tehran and Shiraz in 2013, and the self-reports of specialists. Data on direct non-medical and indirect costs were collected based on the patients' self-reports through face-to-face interviews performed in the mentioned centers. To calculate the indirect costs, friction cost approach was used. To calculate the total cost-of-illness in Iran, the total cost per patient at each stage of the disease was estimated and multiplied by the total number of patients.

resultsThe total annual cost for the activate population of CHB patients and for those receiving treatment at various disease stages were respectively 450 million and 226 million dollars, with 64% and 70% of which allocated to direct costs respectively, and 36% and 30% to indirect costs respectively. The total direct costs alone for each group were respectively 1.17% and 0.6% of the total health expenditure. Furthermore, the cost spent on drugs encompasses the largest proportion of the direct medical cost for all stages of the disease.

conclusionsAccording to the perspectives of payers, patients, and community, CHB infection can be considered as one of the diseases with a substantial economic burden; the disease, specifically in extreme cases, can be too expensive and costly for patients. Therefore, patients should be protected against more severe stages of the disease through proper treatment and early diagnosis.

Indexed as

CHBCost of IllnessDiseases

Identifiers

PMID25977694
PMCPMC4427913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.