ArticleInternational journal of chronic obstructive pulmonary disease2015
Do females behave differently in COPD exacerbation?
Article in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 54 citations in OpenAlex.
- Effect of high-flow nasal therapy during early pulmonary rehabilitation in patients with severe AECOPD: a randomized controlled study.Respiratory research · 2020Trial
- Proteomic profiling of lung immune cells reveals dysregulation of phagocytotic pathways in female-dominated molecular COPD phenotype.Respiratory research · 2018Trial
- Determinants of exacerbation risk in patients with COPD in the TIOSPIR study.International journal of chronic obstructive pulmonary disease · 2017Trial
- Sex Differences in Long-Term Survival of Chronic Obstructive Pulmonary Disease Patients following Initiation of Home Noninvasive Ventilation after Acute Hospitalization due to Respiratory Failure.Respiration; international review of thoracic diseases · 2026Article
- Comparative risk of pneumonia and acute exacerbation between P-CAB and PPI use in patients with COPD and GERD.NPJ primary care respiratory medicine · 2026Article
- Sex differences among inpatients with AECOPD in a tertiary hospital during the COVID-19 pandemic.BMC pulmonary medicine · 2026Article
- Sex and Gender in Chronic Obstructive Pulmonary Disease: Does It Matter?Journal of personalized medicine · 2026Review
- Social determinants of health in clinical trials examining long-term oral antibiotics in COPD: a systematic review.ERJ open research · 2026Review
- Sex differences in asthma and COPD hospital admission, readmission and mortality.BMJ open respiratory research · 2025Article
- Clinical characteristics of chronic obstructive pulmonary disease patients with superoptimal peak inspiratory flow rate.Scientific reports · 2024Article
- Management Reality of Female Patients with COPD: A Multicenter Cross-Sectional CAP Study in Japan.International journal of chronic obstructive pulmonary disease · 2024Observational
- Circulating testosterone levels and health outcomes in chronic obstructive pulmonary disease: results from ECLIPSE and ERICA.BMJ open respiratory research · 2023Observational
- The Role of Early Warning Scoring Systems NEWS and MEWS in the Acute Exacerbation of COPD.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2023Article
- Chronic moderate hypercapnia suppresses ventilatory responses to acute CO<sub>2</sub> challenges.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Associations of air pollutants with pneumonia hospital admissions in Qingdao, China: a prospective cohort study.Environmental science and pollution research international · 2022Article
- Development and Validation of a Multivariable Prediction Model to Identify Acute Exacerbation of COPD and Its Severity for COPD Management in China (DETECT Study): A Multicenter, Observational, Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2022Article
- Exploring the impact of number and type of comorbidities on the risk of severe COPD exacerbations in Korean Population: a Nationwide Cohort Study.BMC pulmonary medicine · 2021Article
- Influence of age, sex and respiratory viruses on the rates of emergency department visits and hospitalisations with respiratory tract infections, asthma and COPD.ERJ open research · 2021Article
- Dyspnoea and symptom burden in mild-moderate COPD: the Canadian Cohort Obstructive Lung Disease Study.ERJ open research · 2021Article
- The Impact of Diabetes Mellitus in Patients with Chronic Obstructive Pulmonary Disease (COPD) Hospitalization.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLittle is known about whether there is any sex effect on chronic obstructive lung disease (COPD) exacerbations. This study is intended to describe the possible sex-associated differences in exacerbation profile in COPD patients.
methodsA total of 384 COPD patients who were hospitalized due to exacerbation were evaluated retrospectively for their demographics and previous and current exacerbation characteristics.
resultsThe study was conducted on 109 (28%) female patients and 275 (72%) male patients. The mean age was 68.30±10.46 years. Although females had better forced expiratory volume in 1 second and near-normal forced vital capacity, they had much impaired arterial blood gas levels (partial oxygen pressure [PO2] was 36.28 mmHg vs 57.93 mmHg; partial carbon dioxide pressure [PCO2] was 45.97 mmHg vs 42.49 mmHg; P=0.001), indicating severe exacerbation with respiratory failure. More females had two exacerbations and two hospitalizations, while more men had one exacerbation and one hospitalization. Low adherence to treatment and pulmonary embolism were more frequent in females. Females had longer time from the onset of symptoms till the admission and longer hospitalization duration than males. Comorbidities were less in number and different in women (P<0.05). Women were undertreated and using more oral corticosteroids.
conclusionCurrent data showed that female COPD patients might be more prone to have severe exacerbations, a higher number of hospitalizations, and prolonged length of stay for hospitalization. They have a different comorbidity profile and might be undertreated for COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.