Evidence map›Paper›PMID 25977445›Full record

ArticleOccupational and environmental medicine2015

Occupational exposures and lung cancer risk among Minnesota taconite mining workers.

Elizabeth M Allen, Bruce H Alexander, Richard F MacLehose, Heather H Nelson, Andrew D Ryan, Gurumurthy Ramachandran, Jeffrey H Mandel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Integration of Evidence on Community Cancer Risks from Elongate Mineral Particles in Silver Bay, Minnesota.Risk analysis : an official publication of the Society for Risk Analysis · 2021
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth M AllenDivision of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USA Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Bruce H AlexanderDivision of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Richard F MacLehoseDivision of Epidemiology, University of Minnesota, Minneapolis, Minnesota, USA.
Heather H NelsonDivision of Epidemiology, University of Minnesota, Minneapolis, Minnesota, USA.
Andrew D RyanDivision of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Gurumurthy RamachandranDivision of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Jeffrey H MandelDivision of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · US

Funding

OCCUPATIONAL SAFETY AND HEALTH EDUCATION AND RESEARCH CENTERS (T42)T42OH008434 · OH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNOLD, SUSAN · 2005 to 2024
$31.3M
Cancer Related Health Disparities Training ProgramT32CA163184 · NCI · UNIVERSITY OF MINNESOTA · PI MICHELE L ALLEN, Irina Stepanov · 2016 to 2026
$3.4M
Cancer Related Health Disparities Education and Career Development ProgramR25CA163184 · NCI · UNIVERSITY OF MINNESOTA · PI FORSTER, JEAN, OKUYEMI, KOLAWOLE S · 2011 to 2015
$2.2M
NCI NIH HHS R25 CA163184NCI NIH HHS R25CA163184NCI NIH HHS T32 CA163184NIOSH CDC HHS 2T42 OH008434NIOSH CDC HHS T42 OH008434
6 · The paper itself

Abstract

objectiveTo examine the association between employment duration, elongate mineral particle (EMP) exposure, silica exposure and the risk of lung cancer in the taconite mining industry.

methodsWe conducted a nested case-control study of lung cancer within a cohort of Minnesota taconite iron mining workers employed by any of the mining companies in operation in 1983. Lung cancer cases were identified by vital records and cancer registry data through 2010. Two age-matched controls were selected from risk sets of cohort members alive and lung cancer free at the time of case diagnosis. Calendar time-specific exposure estimates were made for every job and were used to estimate workers' cumulative exposures. ORs and 95% CIs were estimated using conditional logistic regression. We evaluated total lung cancer risk and risk of histological subtype by total work duration and by cumulative EMP, and silica exposure by quartile of the exposure distribution.

resultsA total of 1706 cases and 3381 controls were included in the analysis. After adjusting for work in haematite mining, asbestos exposure and sex, the OR for total duration of employment was 0.99 (95% CI 0.96 to 1.01). The ORs for quartile 4 versus 1 of EMP and silica exposure were 0.82 (95% CI 0.57 to 1.19) and 0.97 (95% CI 0.70 to 1.35), respectively. The risk of each histological subtype of lung cancer did not change with increasing exposure.

conclusionsThis study suggests that the estimated taconite mining exposures do not increase the risk of developing lung cancer.

Indexed as

Air Pollutants, OccupationalIronMiningSilicatesSilicon DioxideAgedAged, 80 and overAsbestosCase-Control StudiesEmploymentHumansLogistic ModelsLung NeoplasmsMinnesotaOccupational DiseasesOccupational ExposureAir Pollutants, OccupationalAsbestosIronSilicatesSilicon Dioxidetaconite

Identifiers

PMID25977445
PMCPMC4537827
OpenAlexW2150986565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.