ArticleStroke2015
Hemodynamic Features of Symptomatic Vertebrobasilar Disease.
Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph
Article in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00590980 (The Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke), which is not on this map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Study
Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease.JAMA neurology · 2016Trial
- Quantitative Evaluation of Carotid Artery Stenosis by Multi-VENC 4D Flow MRI: Incorporating Turbulent Kinetic Energy for Clinical Validity.Journal of magnetic resonance imaging : JMRI · 2025Article
- Extracranial vertebral artery stenosis patients that may benefit from stent placement: post-hoc analysis from randomized controlled trials.Frontiers in neurology · 2025Article
- Non-traditional lipid parameters are independent predictors of the location, distribution, and stroke events of moderate-to-severe intracranial and extracranial atherosclerotic stenosis.Frontiers in neurology · 2025Article
- Arterial Lesion Location and Outcomes of Intracranial Atherosclerotic Disease.Stroke (Hoboken, N.J.) · 2024Article
- Recurrent stroke risk in intracranial atherosclerotic disease.Frontiers in neurology · 2022Review
- Hemodynamic Disturbances in Posterior Circulation Stroke: 4D Flow Magnetic Resonance Imaging Added to Computed Tomography Angiography.Frontiers in neuroscience · 2021Article
- Safety and Efficacy of Rapamycin-Eluting Vertebral Stents in Patients With Symptomatic Extracranial Vertebral Artery Stenosis.Frontiers in neurology · 2021Article
- Natural History of Hemodynamics in Vertebrobasilar Disease: Temporal Changes in the VERiTAS Study Cohort.Stroke · 2020Observational
- Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study.Journal of the American Heart Association · 2020Observational
- Submaximal Angioplasty for Symptomatic Intracranial Atherosclerotic Disease: A Meta-Analysis of Peri-Procedural and Long-Term Risk.Neurosurgery · 2020Article
- Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Safety and Blood-Flow Outcomes for Hybrid Recanalization in Symptomatic Refractory Long-Segmental Vertebral Artery Occlusion-Results of a Pilot Study.Frontiers in neurology · 2020Article
- Semi-automated analysis of 4D flow MRI to assess the hemodynamic impact of intracranial atherosclerotic disease.Magnetic resonance in medicine · 2019Article
- Hypoperfusion Symptoms Poorly Predict Hemodynamic Compromise and Stroke Risk in Vertebrobasilar Disease.Stroke · 2019Observational
- Recent Advances in Primary and Secondary Prevention of Atherosclerotic Stroke.Journal of stroke · 2018Article
- Higher Stroke Risk with Lower Blood Pressure in Hemodynamic Vertebrobasilar Disease: Analysis from the VERiTAS Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2017Observational
- Evaluating the morphological changes of intracranial arteries and whole-brain perfusion in undetermined isolated vertigo.Journal of the neurological sciences · 2016Article
- Perfusion weighted imaging in the assessment of the pathology and outcomes of lateral medullary infarction.Neurosciences (Riyadh, Saudi Arabia) · 2016Article
- Association between vertebral artery hypoplasia and posterior circulation stroke.BMC neurology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 18 institutions in 8 countries.
Sepideh Amin-HanjaniFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.). hanjani@uic.edu.
Xinjian DuFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Linda Rose-FinnellFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Dilip K PandeyFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
DeJuran RichardsonFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Keith R ThulbornFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Mitchell S V ElkindFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Gregory J ZipfelFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
David S LiebeskindFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Frank L SilverFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Scott E KasnerFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Victor A AletichFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Louis R CaplanFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Colin P DerdeynFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Philip B GorelickFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
Fady T CharbelFrom the Department of Neurosurgery (S.A.-H., X.D., L.R.-F., V.A.A., F.T.C.), Department of Neurology and Rehabilitation (D.K.P., D.R.), and Center for Magnetic Resonance Research (K.R.T.), University of Illinois at Chicago; Department of Mathematics and Computer Science, Lake Forest College, IL (D.R.); Departments of Neurology and Epidemiology, Columbia University, New York, NY (M.S.V.E.); Departments of Neurosurgery and Neurology, Washington University in St. Louis, MO (G.J.Z., C.P.D.); Department of Neurology, University of California at Los Angeles (D.S.L.); Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (F.L.S.); Department of Neurology, University of Pennsylvania, Philadelphia (S.E.K.); Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA (L.R.C.); Departments of Radiology, Neurology and Neurological Surgery, Mallinkrodt Institute of Radiology, Washington University in St. Louis, MO (C.P.D.); and Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, and Mercy Health Hauenstein Neurosciences, Grand Rapids (P.B.G.).
VERiTAS Study Group
Beth Israel Deaconess Medical Center · USMarymount University · USJeffrey Modell Foundation · AUMercy Hospital and Medical Center · USUniversity Physicians · USA.S. Watson (Netherlands) · NLAvila University · USB.E. Meyers & Co (United States) · USBradley Hospital · USBruce Technologies (United States) · USJacobs (United States) · USKalma (Czechia) · CZMartin University · USMettler-Toledo (Switzerland) · CHMichael & Associates · USSan Fernando General Hospital · TTSoutherners on New Ground · USTuran University · KZ
Funding
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWASHINGTON UNIVERSITY NEUROSURGERY RESIDENT RESEARCH EDUCATION PROGRAMR25NS090978 · NINDS · WASHINGTON UNIVERSITY · PI ZIPFEL, GREGORY J · 2015 to 2023
$2.1MVertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and StrokeR01NS059745 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AMIN-HANJANI, SEPIDEH · 2008 to 2012
$2.1MTHE ROLE OF A-BETA SPECIES IN VASCULAR SMOOTH MUSCLE CELL AND CEREBRAL ARTERIOLER01NS071011 · NINDS · WASHINGTON UNIVERSITY · PI ZIPFEL, GREGORY J · 2011 to 2015
$1.6MNCATS NIH HHS UL1 TR000448NINDS NIH HHS R01 NS 059745NINDS NIH HHS R01 NS059745NINDS NIH HHS R01 NS071011NINDS NIH HHS R25 NS090978
Abstract
background and purposeAtherosclerotic vertebrobasilar disease is an important cause of posterior circulation stroke. To examine the role of hemodynamic compromise, a prospective multicenter study, Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS), was conducted. Here, we report clinical features and vessel flow measurements from the study cohort.
methodsPatients with recent vertebrobasilar transient ischemic attack or stroke and ≥50% atherosclerotic stenosis or occlusion in vertebral or basilar arteries (BA) were enrolled. Large-vessel flow in the vertebrobasilar territory was assessed using quantitative MRA.
resultsThe cohort (n=72; 44% women) had a mean age of 65.6 years; 72% presented with ischemic stroke. Hypertension (93%) and hyperlipidemia (81%) were the most prevalent vascular risk factors. BA flows correlated negatively with percentage stenosis in the affected vessel and positively to the minimal diameter at the stenosis site (P<0.01). A relative threshold effect was evident, with flows dropping most significantly with ≥80% stenosis/occlusion (P<0.05). Tandem disease involving the BA and either/both vertebral arteries had the greatest negative impact on immediate downstream flow in the BA (43 mL/min versus 71 mL/min; P=0.01). Distal flow status assessment, based on an algorithm incorporating collateral flow by examining distal vessels (BA and posterior cerebral arteries), correlated neither with multifocality of disease nor with severity of the maximal stenosis.
conclusionsFlow in stenotic posterior circulation vessels correlates with residual diameter and drops significantly with tandem disease. However, distal flow status, incorporating collateral capacity, is not well predicted by the severity or location of the disease.
Indexed as
AdultAgedAged, 80 and overBlood Flow VelocityCerebrovascular CirculationCohort StudiesFemaleHemodynamicsHumansMaleMiddle AgedProspective StudiesRisk FactorsStrokeVertebrobasilar Insufficiencymagnetic resonance angiographymagnetic resonance imagingregional blood flowstrokevertebrobasilar ischemia
Identifiers
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Registered trials
NCT00590980ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.