ArticleDrug and alcohol dependence2015
Methamphetamine injecting is associated with phylogenetic clustering of hepatitis C virus infection among street-involved youth in Vancouver, Canada.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Efficacy and Safety of Modafinil for Treatment of Amphetamine-Type Stimulant Use Disorder: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials: Efficacité et innocuité du modafinil pour le traitement des troubles liés à l'usage de stimulants de type amphétamine : revue systématique et méta-analyse d'essais randomisés contrôlés par placebo.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Pooled it
- Pooled it
- Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022.Public health reports (Washington, D.C. : 1974)Pooled it
- Article
- Associations between prescription stimulant use as prescribed, nonmedical use, and illicit stimulant use among adults evaluated for substance use treatment, 2017-2021.Drug and alcohol dependence reports · 2023Article
- Methamphetamine use in the United States: epidemiological update and implications for prevention, treatment, and harm reduction.Annals of the New York Academy of Sciences · 2022Review
- The hepatitis C epidemic in Canada: An overview of recent trends in surveillance, injection drug use, harm reduction and treatment.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2021Article
- Drugs of Abuse and Their Impact on Viral Pathogenesis.Viruses · 2021Review
- Adverse childhood experiences and stimulant use disorders among adults in the United States.Psychiatry research · 2021Article
- Examining risk behavior and syringe coverage among people who inject drugs accessing a syringe services program: A latent class analysis.The International journal on drug policy · 2020Article
- Resurgent Methamphetamine Use at Treatment Admission in the United States, 2008-2017.American journal of public health · 2020Article
- Increases in methamphetamine use among heroin treatment admissions in the United States, 2008-17.Addiction (Abingdon, England) · 2020Article
- Social values for health technology assessment in Canada: a scoping review of hepatitis C screening, diagnosis and treatment.BMC public health · 2020Article
- Inconsistent temporal patterns of genetic variation of HCV among high-risk subjects may impact inference of transmission networks.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Article
- Role of HCV Viremia in Corroborated HCV Transmission Events Within Young Adult Injecting Partnerships.Open forum infectious diseases · 2019Article
- Direct-Acting Antiviral Treatment Failure Among Hepatitis C and HIV-Coinfected Patients in Clinical Care.Open forum infectious diseases · 2019Article
- Residential eviction predicts initiation of or relapse into crystal methamphetamine use among people who inject drugs: a prospective cohort study.Journal of public health (Oxford, England) · 2019Article
- A latent class approach to identify multi-risk profiles associated with phylogenetic clustering of recent hepatitis C virus infection in Australia and New Zealand from 2004 to 2015.Journal of the International AIDS Society · 2019Article
- Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods.Developmental cognitive neuroscience · 2018Review
- Investments in implementation science are needed to address the harms associated with the sexualized use of substances among gay, bisexual and other men who have sex with men.Journal of the International AIDS Society · 2018Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAmong prospective cohorts of people who inject drugs (PWID), phylogenetic clustering of HCV infection has been observed. However, the majority of studies have included older PWID, representing distant transmission events. The aim of this study was to investigate phylogenetic clustering of HCV infection among a cohort of street-involved youth.
methodsData were derived from a prospective cohort of street-involved youth aged 14-26 recruited between 2005 and 2012 in Vancouver, Canada (At Risk Youth Study, ARYS). HCV RNA testing and sequencing (Core-E2) were performed on HCV positive participants. Phylogenetic trees were inferred using maximum likelihood methods and clusters were identified using ClusterPicker (Core-E2 without HVR1, 90% bootstrap threshold, 0.05 genetic distance threshold).
resultsAmong 945 individuals enrolled in ARYS, 16% (n=149, 100% recent injectors) were HCV antibody positive at baseline interview (n=86) or seroconverted during follow-up (n=63). Among HCV antibody positive participants with available samples (n=131), 75% (n=98) had detectable HCV RNA and 66% (n=65, mean age 23, 58% with recent methamphetamine injection, 31% female, 3% HIV+) had available Core-E2 sequences. Of those with Core-E2 sequence, 14% (n=9) were in a cluster (one cluster of three) or pair (two pairs), with all reporting recent methamphetamine injection. Recent methamphetamine injection was associated with membership in a cluster or pair (P=0.009).
conclusionIn this study of street-involved youth with HCV infection and recent injecting, 14% demonstrated phylogenetic clustering. Phylogenetic clustering was associated with recent methamphetamine injection, suggesting that methamphetamine drug injection may play an important role in networks of HCV transmission.
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