ArticleBMJ open2015
Time-varying impact of comorbidities on mortality after liver transplantation: a national cohort study using linked clinical and administrative data.
Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- Pretransplant diabetes mellitus predicts worse outcomes of liver transplantation: evidence from meta-analysis.Journal of endocrinological investigation · 2018Pooled it
- Association Between Cytomegalovirus Viremia Clearance and Post-Solid Organ Transplant Mortality in Patients With Refractory Cytomegalovirus Infection: SOLSTICE Post Hoc Analysis.Transplant international : official journal of the European Society for Organ Transplantation · 2025Trial
- Risk factors associated with adverse cardiovascular events during orthotopic liver transplantation and the early post-transplant period.Croatian medical journal · 2025Article
- Risk Evaluation and Recipient Selection in Adult Liver Transplantation: A Mixed-Methods Survey.Canadian liver journal · 2024Article
- Comparing Functional Frailty and Radiographic Sarcopenia as Predictors of Outcomes After Liver Transplant.Clinical transplantation · 2024Article
- Normothermic Machine Perfusion Reduces Transfusion Requirements Even After Static Cold Storage: A 1 y Retrospective Single-center Analysis.Transplantation direct · 2024Article
- The Hemodynamic Profile and Intraoperative Bleeding Impact on Liver Transplant Patients.Journal of personalized medicine · 2024Article
- Estimation of lifetime costs for patients receiving a transplant: the case of liver transplantation related to hepatitis B in Italy.Frontiers in public health · 2024Article
- Observational Study of the Association between Atrial Fibrillation and In-Hospital Mortality during Hospitalization for Solid Organ Transplants in Spain from 2004 to 2021.Journal of clinical medicine · 2023Article
- Association between Hospital-Acquired Pneumonia and In-Hospital Mortality in Solid Organ Transplant Admissions: An Observational Analysis in Spain, 2004-2021.Journal of clinical medicine · 2023Article
- Mortality among solid organ transplant recipients with a pretransplant cancer diagnosis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Multi-Task Learning for Post-transplant Cause of Death Analysis: A Case Study on Liver Transplant.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation.Annals of medicine · 2022Article
- Liver transplantation during COVID-19: Adaptive measures with future significance.World journal of transplantation · 2022Review
- Cardiac risk stratification of the liver transplant candidate: A comprehensive review.World journal of transplantation · 2022Review
- Impact of COVID-19 Infection on Children and Adolescents after Liver Transplantation in a Latin American Reference Center.Microorganisms · 2022Article
- Coronary Artery Disease Assessment During Evaluation for Liver Transplantation: How Much Does It Matter?Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2022Article
- Advantages of using indocyanine green in liver transplantation: a narrative review.Annals of translational medicine · 2022Review
- The liver transplant risk score prognosticates the outcomes of liver transplant recipients at listing.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe assessed the impact of comorbidity on mortality in three periods after liver transplantation (first 90 days, 90 days-5 years and 5-10 years).
designProspective cohort study using records from the UK Liver Transplant Audit (UKLTA) linked to Hospital Episode Statistics (HES), an administrative database of hospital admissions in the English National Health Service (NHS). Comorbidities relevant for liver transplantation were identified from the 10th revision of the International Classification of Diseases (ICD-10) codes in HES records of admissions in the year preceding their operation. Multivariable Cox regression was used to estimate HRs for three different time periods after liver transplantation.
settingAll liver transplant centres in the NHS hospitals in England.
participantsAdults who received a first elective liver transplant between April 1997 and March 2010 in the linked UKLTA-HES database. OUTCOMES: Patient mortality in three different time periods after transplantation.
resultsAmong 3837 recipients, 45.1% had comorbidities. Recipients with cardiovascular disease had statistically significantly higher mortality in all three periods after transplantation (first 90 days: HR=2.0; 95% CI 1.4 to 2.9, 90 days-5 years: 1.6; 1.2 to 2.2, beyond 5 years: 2.8; 1.7 to 4.4). Prior congestive cardiac failure (3.2; 2.1 to 4.9) significantly increased mortality only in the first 90 days. History of non-hepatic malignancy appeared to increase risk over all periods, but significantly only in the first 90 days (1.9; 1.0 to 3.6). A diagnosis of connective tissue disease, dementia, diabetes, chronic pulmonary and renal disease did not have a significant impact on mortality in any period.
conclusionsThe impact of comorbidities present at the time of transplantation changes with time after transplantation. Renal disease, pulmonary disease and diabetes had no impact on mortality in contrast to previous reports.
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