ReviewJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2015
Proteomics approaches shed new light on hibernation physiology.
Review in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Proteomic Mechanisms of Hepatic- and Cardio-Protection of a Food-Hoarding Hibernator, Tamias sibiricus.Integrative zoology · 2026Article
- A One Health Framework for Proteomics Across the Tree of Life to Advance Food Security, Animal Health, and Ecosystem Resilience.Proteomes · 2026Review
- Serum proteome of the Egyptian rousette bat (Rousettus aegyptiacus) reveals signatures of immunity, proteostasis, and metabolism.Scientific reports · 2026Article
- Protein Sample Preparation for Bottom-Up, Label-Free Quantitative Proteomics of Adipose Tissue.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Molecular mechanisms of adaptive evolution in wild animals and plants.Science China. Life sciences · 2023Review
- Differential AMPK-mediated metabolic regulation observed in hibernation-style polymorphisms in Siberian chipmunks.Frontiers in physiology · 2023Article
- Non-shivering thermogenesis is differentially regulated during the hibernation season in Arctic ground squirrels.Frontiers in physiology · 2023Article
- Elevated plasma phospholipid n-3 docosapentaenoic acid concentrations during hibernation.PloS one · 2023Article
- Big brown bats experience slower epigenetic ageing during hibernation.Proceedings. Biological sciences · 2022Article
- Liver Transcriptome Dynamics During Hibernation Are Shaped by a Shifting Balance Between Transcription and RNA Stability.Frontiers in physiology · 2021Article
- Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California.Nature communications · 2020Article
- Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel.Communications biology · 2019Article
- Hibernation in bats (Mammalia: Chiroptera) did not evolve through positive selection of leptin.Ecology and evolution · 2018Article
- A sample preparation workflow for adipose tissue shotgun proteomics and proteogenomics.Biology open · 2018Article
- Gene expression profiling during hibernation in the European hamster.Scientific reports · 2018Article
- Nature's fat-burning machine: brown adipose tissue in a hibernating mammal.The Journal of experimental biology · 2018Review
- Changes in the phosphoproteome of brown adipose tissue during hibernation in the ground squirrel,Physiological genomics · 2017Article
- Neural Signaling Metabolites May Modulate Energy Use in Hibernation.Neurochemical research · 2017Review
- Seasonal and post-trauma remodeling in cone-dominant ground squirrel retina.Experimental eye research · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The broad phylogenetic distribution and rapid phenotypic transitions of mammalian hibernators imply that hibernation is accomplished by differential expression of common genes. Traditional candidate gene approaches have thus far explained little of the molecular mechanisms underlying hibernation, likely due to (1) incomplete and imprecise sampling of a complex phenotype, and (2) the forming of hypotheses about which genes might be important based on studies of model organisms incapable of such dynamic physiology. Unbiased screening approaches, such as proteomics, offer an alternative means to discover the cellular underpinnings that permit successful hibernation and may reveal previously overlooked, important pathways. Here, we review the findings that have emerged from proteomics studies of hibernation. One striking feature is the stability of the proteome, especially across the extreme physiological shifts of torpor-arousal cycles during hibernation. This has led to subsequent investigations of the role of post-translational protein modifications in altering protein activity without energetically wasteful removal and rebuilding of protein pools. Another unexpected finding is the paucity of universal proteomic adjustments across organ systems in response to the extreme metabolic fluctuations despite the universality of their physiological challenges; rather each organ appears to respond in a unique, tissue-specific manner. Additional research is needed to extend and synthesize these results before it will be possible to address the whole body physiology of hibernation.
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Registered trials
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