ReviewAllergy and asthma proceedings
Food protein-induced enterocolitis syndrome and allergic proctocolitis.
Review in Allergy and asthma proceedings. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 152 citations in OpenAlex.
- Effect of Maternal Diet on Any Necrotizing Enterocolitis in Neonates: A Randomized Double-Blind Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022Trial
- Article
- Mucous Stools in Infancy as an Early Marker of the Atopic March: A Four-Year Cohort Study of Respiratory Atopy Risk.Children (Basel, Switzerland) · 2026Article
- From the Field - Supporting Families as They Navigate Infant Food Allergies.Journal of human lactation : official journal of International Lactation Consultant Association · 2026Review
- Evaluating the effectiveness of elimination diet in infants with CMP-induced allergic proctocolitis using CoMiSS.Pediatric research · 2026Article
- Diagnosis and Management of Food Protein-Induced Allergic Proctocolitis.Current gastroenterology reports · 2025Review
- Analysis of Clinical Characteristics of Refractory Food Protein-Induced Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Allergic proctocolitis: Evaluation and management.Journal of food allergy · 2025Review
- Sensitization to common food allergens in infants with food protein-induced allergic proctocolitis: A prospective study.Asia Pacific allergy · 2025Article
- Observational
- Individualized Nutritional Counseling Closes Growth and Nutrition Gaps in Infants With Food Protein-Induced Allergic Proctocolitis: 6-Month Follow-Up Study.Food science & nutrition · 2025Article
- The Immunological Mechanisms Involved in the Pathophysiology of Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Discrepancy between Mexican paediatricians and ESPGHAN experts regarding cow's milk allergy.JPGN reports · 2025Article
- Food Protein-Induced Allergic Proctocolitis: Real-World Experience from an Italian Cohort.Nutrients · 2024Observational
- Duration of food protein-induced allergic proctocolitis (FPIAP) and the role of intestinal microbiota.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Observational
- Can Faecal Zonulin and Calprotectin Levels Be Used in the Diagnosis and Follow-Up in Infants with Milk Protein-Induced Allergic Proctocolitis?Nutrients · 2024Observational
- Wheat-Related Disorders in Children: A 360-Degree View.Children (Basel, Switzerland) · 2024Review
- Review
- Development of IgE-mediated food allergies in children with history of food protein-induced allergic proctocolitis: a series of five cases.Frontiers in allergy · 2024Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-IgE-mediated food allergic disorders account for up to 40% of milk protein allergy in infants and young children. We aim to review the recent literature and to provide an update on diagnosis and management of food protein-induced enterocolitis syndrome (FPIES) and food protein-induced allergic proctocolitis (FPIAP). The peer-reviewed articles indexed in PubMed have been reviewed. FPIES manifests in infants as profuse, repetitive vomiting and lethargy, often with diarrhea, leading to acute dehydration, or weight loss and failure to thrive, in chronic form. FPIES is caused most commonly by cow's milk (CM) and soy proteins; rice, oat, and other solid foods may also trigger FPIES. FPIES rarely occurs in the exclusively breastfed infants. FPIES is underrecognized; children are often mismanaged as having acute viral gastrointestinal illness, sepsis, or surgical disease, delaying diagnosis of FPIES for many months. Approximately 25% of children with FPIES develop food-specific IgE antibodies and some transition to immediate food allergy; IgE positivity is associated with a more protracted course. FPIES is a self-limiting condition, with most cases resolving by age three to five years. Ondansetron may be helpful in managing acute FPIES. FPIAP is a benign condition of bloody stools in a well-appearing infant, with usual onset between one and four weeks of age. Up to 60% of cases occur in exclusively breastfed infants and resolve with maternal elimination of CM and soy proteins. The majority of cases resolve by age 12 months. FPIES may transition to IgE-mediated food allergy in some patients; IgE positivity to the FPIES food is a marker of a more persistent disease. FPIAP is benign and resolves by age 12 months in most patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.