ArticleMolecular biology and evolution2015
Temperature-Related Reaction Norms of Gene Expression: Regulatory Architecture and Functional Implications.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 70 citations in OpenAlex.
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- Differences in temperature-sensitive expression of PcG-regulated genes among natural populations of Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
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- The Evolution of Phenotypic Plasticity in Response to Temperature Stress.Genome biology and evolution · 2020Article
- Genotype by environment interaction for gene expression in Drosophila melanogaster.Nature communications · 2020Article
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- Evolution and Plasticity of the Transcriptome Under Temperature Fluctuations in the Fungal Plant PathogenFrontiers in microbiology · 2020Article
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- Genomics of Developmental Plasticity in Animals.Frontiers in genetics · 2019Review
- An Automated Method to Determine the Performance of Drosophila in Response to Temperature Changes in Space and Time.Journal of visualized experiments : JoVE · 2018Article
- Effects of acclimation time and epigenetic mechanisms on growth of Neurospora in fluctuating environments.Heredity · 2018Article
- A simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila.Genome biology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The environment has profound effects on the expression of many traits and reaction norms describe the expression dynamics of a trait across a broad range of environmental conditions. Here, we analyze gene expression in Drosophila melanogaster across four different developmental temperatures (13-29 °C). Gene expression is highly plastic with 83.3% of the genes being differentially expressed. We distinguished three components of plasticity: 1) Dynamics of gene expression intensity (sum of change), 2) direction of change, and 3) curvature of the reaction norm (linear vs. quadratic). Studying their regulatory architecture we found that all three plasticity components were most strongly affected by the number of different transcription factors (TFs) binding to the target gene. More TFs were found in genes with less expression changes across temperatures. Although the effect of microRNAs was weaker, we consistently noted a trend in the opposite direction. The most plastic genes were regulated by fewer TFs and more microRNAs than less plastic genes. Different patterns of plasticity were also reflected by their functional characterization based on gene ontology. Our results suggest that reaction norms provide an important key to understand the functional requirements of natural populations exposed to variable environmental conditions.
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