ArticleScientific reports2015
Functional Characterization of Novel Sesquiterpene Synthases from Indian Sandalwood, Santalum album.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 88 citations in OpenAlex.
- The AREB transcription factor SaAREB6 promotes drought stress-induced santalol biosynthesis in sandalwood.Horticulture research · 2025Article
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- Biological Properties of Sandalwood Oil and Microbial Synthesis of Its Major Sesquiterpenoids.Biomolecules · 2024Review
- Simulation-Guided Engineering Enables a Functional Switch in Selinadiene Synthase toward Hydroxylation.ACS catalysis · 2024Article
- Integrated mRNA and small RNA sequencing reveals post-transcriptional regulation of the sesquiterpene pathway in3 Biotech · 2023Article
- Impact of Agro-Industrial Side-Streams on Sesquiterpene Production by Submerged CulturedFoods (Basel, Switzerland) · 2023Article
- Identification and characterization of novel sesquiterpene synthases TPS9 and TPS12 fromPeerJ · 2023Article
- Functional characterization of a farnesyl diphosphate synthase from Dendrobium nobile Lindl.AMB Express · 2022Article
- Identification and Functional Analysis of SabHLHs inLife (Basel, Switzerland) · 2022Article
- Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy.Molecules (Basel, Switzerland) · 2022Review
- Article
- Cloning and expression analysis of mevalonate kinase and phosphomevalonate kinase genes associated with the MVA pathway in Santalum album.Scientific reports · 2021Article
- Molecular Cloning and Functional Analysis of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase fromGenes · 2021Article
- Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis.ACS catalysis · 2021Article
- Cloning, characterization, and functional analysis of acetyl-CoA C-acetyltransferase and 3-hydroxy-3-methylglutaryl-CoA synthase genes in Santalum album.Scientific reports · 2021Article
- Advances in biotechnological production of santalenes and santalols.Chinese herbal medicines · 2021Review
- Study on Lavender Essential Oil Chemical Compositions by GC-MS and Improved pGC.Molecules (Basel, Switzerland) · 2020Article
- EnhancingEngineering in life sciences · 2019Article
- Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product.ACS chemical biology · 2019Article
- Identification and functional characterization of three new terpene synthase genes involved in chemical defense and abiotic stresses in Santalum album.BMC plant biology · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indian Sandalwood, Santalum album L. is highly valued for its fragrant heartwood oil and is dominated by a blend of sesquiterpenes. Sesquiterpenes are formed through cyclization of farnesyl diphosphate (FPP), catalyzed by metal dependent terpene cyclases. This report describes the cloning and functional characterization of five genes, which encode two sesquisabinene synthases (SaSQS1, SaSQS2), bisabolene synthase (SaBS), santalene synthase (SaSS) and farnesyl diphosphate synthase (SaFDS) using the transcriptome sequencing of S. album. Using Illumina next generation sequencing, 33.32 million high quality raw reads were generated, which were assembled into 84,094 unigenes with an average length of 494.17 bp. Based on the transcriptome sequencing, five sesquiterpene synthases SaFDS, SaSQS1, SaSQS2, SaBS and SaSS involved in the biosynthesis of FPP, sesquisabinene, β-bisabolene and santalenes, respectively, were cloned and functionally characterized. Novel sesquiterpene synthases (SaSQS1 and SaSQS2) were characterized as isoforms of sesquisabinene synthase with varying kinetic parameters and expression levels. Furthermore, the feasibility of microbial production of sesquisabinene from both the unigenes, SaSQS1 and SaSQS2 in non-optimized bacterial cell for the preparative scale production of sesquisabinene has been demonstrated. These results may pave the way for in vivo production of sandalwood sesquiterpenes in genetically tractable heterologous systems.
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