ArticleThe Journal of comparative neurology2015
Differential distribution of GABA and glycine terminals in the inferior colliculus of rat and mouse.
Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain.The Journal of comparative neurology · 2026Article
- Anatomical and neurochemical profiles of GABAergic projection neurons in the mouse inferior colliculus.Brain structure & function · 2025Article
- GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.The Journal of physiology · 2025Article
- The Ventral Tectal Longitudinal Column: A Midbrain Nucleus for Modulation of Auditory Processing in the Cochlear Nucleus, Superior Olivary Complex, and Inferior Colliculus.The Journal of comparative neurology · 2025Article
- Expression of group II mGluRs in the inferior colliculus, medial geniculate body, and auditory cortex increases with age.Neuroscience · 2025Article
- Differential cholinergic innervation of lemniscal versus non-lemniscal regions of the inferior colliculus.Journal of chemical neuroanatomy · 2024Article
- Two Prediction Error Systems in the Nonlemniscal Inferior Colliculus: "Spectral" and "Nonspectral".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Noise-induced hearing loss alters potassium-chloride cotransporter KCC2 and GABA inhibition in the auditory centers.Scientific reports · 2024Article
- Article
- GluN2C/D-containing NMDA receptors enhance temporal summation and increase sound-evoked and spontaneous firing in the inferior colliculus.bioRxiv : the preprint server for biology · 2024Article
- Identifying neuron types and circuit mechanisms in the auditory midbrain.Hearing research · 2024Review
- Sequential maturation of stimulus-specific adaptation in the mouse lemniscal auditory system.Science advances · 2024Article
- Noise-Induced Hearing Loss Alters Potassium-Chloride CoTransporter KCC2 and GABA Inhibition in the auditory centers.Research square · 2023Article
- Neuronal responses to omitted tones in the auditory brain: A neuronal correlate for predictive coding.Science advances · 2023Article
- Cholinergic Boutons are Distributed Along the Dendrites and Somata of VIP Neurons in the Inferior Colliculus.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Depolarization shift in the resting membrane potential of inferior colliculus neurons explains their hyperactivity induced by an acoustic trauma.Frontiers in neuroscience · 2023Article
- Eph and ephrin signaling in the development of the central auditory system.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Inhibitory NPY Neurons Provide a Large and Heterotopic Commissural Projection in the Inferior Colliculus.Frontiers in neural circuits · 2022Article
- Absence of the Fragile X messenger ribonucleoprotein alters response patterns to sounds in the auditory midbrain.Frontiers in neuroscience · 2022Article
- Cholinergic boutons are closely associated with excitatory cells and four subtypes of inhibitory cells in the inferior colliculus.Journal of chemical neuroanatomy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The inferior colliculus (IC), the midbrain component of the auditory pathway, integrates virtually all inputs from the auditory brainstem. These are a mixture of excitatory and inhibitory ascending inputs, and the inhibitory transmitters include both gamma-aminobutyric acid (GABA) and glycine (GLY). Although the presence of these inhibitory inputs is well established, their relative location in the IC is not, and there is little information on the mouse. Here, we study the distribution of glutamic acid decarboxylase (GAD)67 and GLY transporter 2 (T2) in axonal terminals to better understand the relative contributions of these inputs. Large-scale mosaic composite images of immunohistochemistry sections of rat and mice were used to isolate the signals related to the concentrations of these axonal terminals in the tissue, and the ratio of GLYT2/GAD67 in each pixel was calculated. GLYT2 was seen only in the central nucleus of the IC (ICC), whereas GAD67 was seen throughout the IC. The map of the GAD67 and GLYT2 axonal distribution revealed a gradient that runs from ventrolateral to dorsomedial along the axis of the laminae of the ICC and perpendicular to the tonotopic axis. Although anatomically different, both the mouse and the rat had relatively more GAD67 dorsomedially in the ICC and relatively more GLYT2 ventrolaterally. This organization of GABA and GLY inputs may be related to functional zones with different properties in ICC that are based, in part, on different sets of inhibitory inputs to each zone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.