ArticleMolecular plant pathology2016
PsHint1, associated with the G-protein α subunit PsGPA1, is required for the chemotaxis and pathogenicity of Phytophthora sojae.
Article in Molecular plant pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Oomycete plant pathogens: biology, pathogenesis and emerging control strategies.Nature reviews. Microbiology · 2026Review
- The oligosaccharyltransferase subunit PsSTT3A regulates N-glycosylation and is critical for development and virulence of Phytophthora sojae.Science China. Life sciences · 2025Article
- A Protein with Unknown Function, Ps495620, Is Critical for the Sporulation and Oospore Production ofJournal of fungi (Basel, Switzerland) · 2024Article
- Decoding the biochemical dialogue: metabolomic insights into soybean defense strategies against diverse pathogens.Science China. Life sciences · 2024Article
- A Novel FYVE Domain-Containing Protein Kinase, PsZFPK1, Plays a Critical Role in Vegetative Growth, Sporangium Formation, Oospore Production, and Virulence inJournal of fungi (Basel, Switzerland) · 2023Article
- Phase-specific transcriptional patterns of the oomycete pathogen Phytophthora sojae unravel genes essential for asexual development and pathogenic processes.PLoS pathogens · 2023Article
- Signal and regulatory mechanisms involved in spore development ofFrontiers in microbiology · 2022Review
- Article
- Phytopathogenic oomycetes: a review focusing on Phytophthora cinnamomi and biotechnological approaches.Molecular biology reports · 2020Review
- Organize, Don't Agonize: Strategic Success ofMicroorganisms · 2020Review
- Review
- G protein α subunit suppresses sporangium formation through a serine/threonine protein kinase in Phytophthora sojae.PLoS pathogens · 2020Article
- Exchanges at the Plant-Oomycete Interface That Influence Disease.Plant physiology · 2019Review
- Effects of Different G-Protein α-Subunits on Growth, Development and Secondary Metabolism ofFrontiers in microbiology · 2019Article
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zoospore chemotaxis to soybean isoflavones is essential in the early stages of infection by the oomycete pathogen Phytophthora sojae. Previously, we have identified a G-protein α subunit encoded by PsGPA1 which regulates the chemotaxis and pathogenicity of P. sojae. In the present study, we used affinity purification to identify PsGPA1-interacting proteins, including PsHint1, a histidine triad (HIT) domain-containing protein orthologous to human HIT nucleotide-binding protein 1 (HINT1). PsHint1 interacted with both the guanosine triphosphate (GTP)- and guanosine diphosphate (GDP)-bound forms of PsGPA1. An analysis of the gene-silenced transformants revealed that PsHint1 was involved in the chemotropic response of zoospores to the isoflavone daidzein. During interaction with a susceptible soybean cultivar, PsHint1-silenced transformants displayed significantly reduced infectious hyphal extension and caused a strong cell death in plants. In addition, the transformants displayed defective cyst germination, forming abnormal germ tubes that were highly branched and exhibited apical swelling. These results suggest that PsHint1 not only regulates chemotaxis by interacting with PsGPA1, but also participates in a Gα-independent pathway involved in the pathogenicity of P. sojae.
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