Evidence map›Paper›PMID 25976083›Full record

ReviewPeptides2015

Insights into bombesin receptors and ligands: Highlighting recent advances.

Irene Ramos-Álvarez, Paola Moreno, Samuel A Mantey, Taichi Nakamura, Bernardo Nuche-Berenguer, Terry W Moody, David H Coy, Robert T Jensen

Open access · greenAbstract readHistorical ArticleReview
In one paragraph

Review in Peptides, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Clinical impact of [Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  4. Article
  5. Review
  6. Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
  8. Synthesis, preclinical, and initial clinical evaluation of integrin αEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Irene Ramos-ÁlvarezDigestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
Paola MorenoDigestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
Samuel A ManteyDigestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
Taichi NakamuraDigestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
Bernardo Nuche-BerenguerDigestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
Terry W MoodyCenter for Cancer Research, Office of the Director, NCI, National Institutes of Health, Bethesda, MD 20892-1804, United States.
David H CoyPeptide Research Laboratory, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, United States.
Robert T JensenDigestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States. Electronic address: robertj@bdg10.niddk.nih.gov.
National Institutes of Health · USTulane University · US

Funding

Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factorsZIADK053101 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JENSEN, ROBERT · 2009 to 2025
$12.9M
Characterization And Pharmacology Of Receptors For Gastrointestinal PeptidesZIADK053100 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JENSEN, ROBERT · 2009 to 2025
$12.7M
Cellular Basis Of Action Of Gastrointestinal Peptides/Growth factorsZ01DK053101 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JENSEN, ROBERT · 1990 to 2008
$726k
IDENTIFICATION AND CHARACTERIZATION OF RECEPTORS FOR GI PEPTIDESZ01DK053100 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JENSEN, ROBERT · 1990 to 2008
$724k
Intramural NIH HHS Z01 DK053100Intramural NIH HHS Z01 DK053101
6 · The paper itself

Abstract

This following article is written for Prof. Abba Kastin's Festschrift, to add to the tribute to his important role in the advancement of the role of peptides in physiological, as well as pathophysiological processes. There have been many advances during the 35 years of his prominent role in the Peptide field, not only as editor of the journal Peptides, but also as a scientific investigator and editor of two volumes of the Handbook of Biological Active Peptides [146,147]. Similar to the advances with many different peptides, during this 35 year period, there have been much progress made in the understanding of the pharmacology, cell biology and the role of (bombesin) Bn receptors and their ligands in various disease states, since the original isolation of bombesin from skin of the European frog Bombina bombina in 1970 [76]. This paper will briefly review some of these advances over the time period of Prof. Kastin 35 years in the peptide field concentrating on the advances since 2007 when many of the results from earlier studies were summarized [128,129]. It is appropriate to do this because there have been 280 articles published in Peptides during this time on bombesin-related peptides and it accounts for almost 5% of all publications. Furthermore, 22 Bn publications we have been involved in have been published in either Peptides [14,39,55,58,81,92,93,119,152,216,225,226,231,280,302,309,355,361,362] or in Prof. Kastin's Handbook of Biological Active Peptides [137,138,331].

Indexed as

AnimalsHistory, 20th CenturyHistory, 21st CenturyHumansLigandsPeptidesPeriodicals as TopicReceptors, BombesinLigandsPeptidesReceptors, BombesinBombesinGastrin releasing peptideNeuromedin bObesityPruritus

Identifiers

PMID25976083
PMCPMC4641779
OpenAlexW219756805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.