Evidence map›Paper›PMID 25976060›Full record

ArticleBrain pathology (Zurich, Switzerland)2016

MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim.

Huiqing Wang, Yongyi Ye, Zhiyuan Zhu, Liqian Mo, Chunnan Lin, Qifu Wang, Haoyuan Wang, Xin Gong, Xiaozheng He, Guohui Lu and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 1 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 1 synthesis or guideline pooled it, 185 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026
    Review
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  12. PTEN: a new dawn in Parkinson's disease treatment.Frontiers in cellular neuroscience · 2025
    Review
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  14. Review
  15. Review
  16. Review
  17. Article
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Huiqing WangDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yongyi YeDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhiyuan ZhuDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Liqian MoDepartment of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chunnan LinDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Qifu WangDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Haoyuan WangDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Xin GongThe National Key Clinic Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Southern Medical University, Guangzhou, China.
Xiaozheng HeDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Guohui LuDepartment of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Fengfei LuDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Shizhong ZhangDepartment of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Southern Medical University · CNZhujiang Hospital · CNFirst Affiliated Hospital of Nanchang University · CNHunan Provincial People's Hospital · CNNanfang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is the most prevalent movement disorder characterized by selective loss of midbrain dopaminergic (DA) neurons. MicroRNA-124 (miR-124) is abundantly expressed in the DA neurons and its expression level decreases in the 1-methyl-4-pheny-1, 2, 3, 6-tetrahydropyridine (MPTP) model of PD. However, whether the upregulation of miR-124 could attenuate neurodegeneration remains unknown. Here, we employed miR-124 agomir and miR-124 mimics to upregulate miR-124 expression in MPTP-treated mice and MPP(+) -intoxicated SH-SY5Y cells, respectively. We found that loss of DA neurons and striatal dopamine in MPTP-treated mice was significantly reduced by upregulating miR-124. In addition, we identified a target of miR-124, Bim that mediated the neuroprotection of miR-124. Indeed, treatment of miR-124 agomir in MPTP-treated mice inhibited Bim expression, thus suppressing Bax translocation to mitochondria. Moreover, impaired autophagy process in MPTP-treated mice and MPP(+) -intoxicated SH-SY5Y cells characterized as autophagosomes (AP) accumulation and lysosomal depletion were alleviated by the upregulation of miR-124. Taken together, these results indicate that upregulation of miR-124 could regulate apoptosis and impaired autophagy process in the MPTP model of PD, thus reducing the loss of DA neurons.

Indexed as

Active Transport, Cell NucleusAnimalsApoptosisAutophagybcl-2-Associated X ProteinBcl-2-Like Protein 11Cell Line, TumorCorpus StriatumDopamineDopaminergic NeuronsHumansMaleMice, Inbred C57BLMicroRNAsMPTP PoisoningUp-RegulationBax protein, mousebcl-2-Associated X ProteinBCL2L11 protein, humanBcl2l11 protein, mouseBcl-2-Like Protein 11DopamineMicroRNAsMIRN124 microRNA, humanMirn124 microRNA, mouseapoptosisautophagyBaxBimmiR-124Parkinson's disease

Identifiers

PMID25976060
PMCPMC8029438
OpenAlexW2139296565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.